SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 297
THR A 238
THR A 294
ILE A 299
 None
 0.84A 1gtnD-5yg7A:
undetectable
1gtnE-5yg7A:
undetectable		 1gtnD-5yg7A:
undetectable
1gtnE-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 297
THR A 238
THR A 294
ILE A 299
 None
 0.86A 1gtnF-5yg7A:
undetectable
1gtnG-5yg7A:
undetectable		 1gtnF-5yg7A:
undetectable
1gtnG-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 297
THR A 238
THR A 294
ILE A 299
 None
 0.87A 1gtnJ-5yg7A:
undetectable
1gtnK-5yg7A:
undetectable		 1gtnJ-5yg7A:
undetectable
1gtnK-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  35
GLN A  38
GLU A  49
GLU A  53
ALA A  57
 None
 1.50A 1wrkA-5yg7A:
undetectable
1wrkB-5yg7A:
undetectable		 1wrkA-5yg7A:
20.45
1wrkB-5yg7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 PHE A 106
ALA A  32
ALA A  34
LEU A  61
ALA A  13
 None
 1.15A 2bxeA-5yg7A:
2.5		 2bxeA-5yg7A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 5 ASN A  73
ALA A 203
GLY A  25
THR A  64
 None
None
RI2  A 401 (-3.5A)
None
 0.86A 3dl9A-5yg7A:
undetectable		 3dl9A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 MET A  19
CYH A 135
PRO A 163
 RI2  A 401 (-4.5A)
RI2  A 401 (-3.6A)
None
 1.00A 3h52C-5yg7A:
undetectable		 3h52C-5yg7A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 4 PHE A 241
LYS A 240
ILE A 307
THR A 245
 None
RI2  A 401 (-2.8A)
None
None
 0.96A 3ia4B-5yg7A:
2.9		 3ia4B-5yg7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 5 ASN A 209
ALA A 211
PRO A 286
ALA A 304
 G  A 404 (-3.5A)
G  A 404 (-3.3A)
None
None
 1.41A 3twpD-5yg7A:
undetectable		 3twpD-5yg7A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 237
TYR A 239
SER A  70
 RI2  A 401 ( 4.3A)
None
None
 0.94A 4at0A-5yg7A:
undetectable		 4at0A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 245
ILE A 213
ILE A 292
ALA A 236
PHE A 241
 None
 1.11A 4rp8C-5yg7A:
undetectable		 4rp8C-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  34
LEU A  61
TYR A 239
ILE A 206
GLY A 202
PHE A 106
 None
None
None
None
RI2  A 401 ( 3.9A)
None
 1.38A 5eshA-5yg7A:
undetectable		 5eshA-5yg7A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 ILE A 299
PRO A 300
ILE A 292
 None
 0.45A 5hw8F-5yg7A:
undetectable		 5hw8F-5yg7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 260
ALA A  24
PHE A 281
ASN A 204
LYS A 215
 None
RI2  A 401 (-3.6A)
RI2  A 401 (-4.4A)
RI2  A 401 (-2.7A)
RI2  A 401 (-2.8A)
 1.34A 5kc4E-5yg7A:
undetectable		 5kc4E-5yg7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A  72
LYS A 240
THR A  67
TYR A  62
 None
RI2  A 401 (-2.8A)
None
None
 1.28A 5x2sI-5yg7A:
undetectable
5x2sJ-5yg7A:
undetectable
5x2sK-5yg7A:
undetectable		 5x2sI-5yg7A:
20.90
5x2sJ-5yg7A:
20.55
5x2sK-5yg7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  25
ALA A  31
SER A  70
LEU A  71
ASN A  73
 RI2  A 401 (-3.5A)
None
None
None
None
 1.18A 5x6yB-5yg7A:
2.4		 5x6yB-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 162
LYS A 168
TYR A 183
 None
 1.38A 6gnaA-5yg7A:
undetectable		 6gnaA-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 162
LYS A 168
TYR A 183
 None
 1.38A 6gnbA-5yg7A:
undetectable		 6gnbA-5yg7A:
undetectable