SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5yge AMINO-ACID
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  76
LEU A 109
LEU A 107
VAL A 103
LEU A 100
ALA A  67
 None
None
None
None
None
GLU  A 202 ( 3.7A)
 1.37A 1gseB-5ygeA:
undetectable		 1gseB-5ygeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yge AMINO-ACID
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  66
GLY A  91
PHE A 121
PHE A 122
 None
ACO  A 201 (-3.2A)
ACO  A 201 ( 4.4A)
ACO  A 201 (-4.6A)
 0.88A 2qwxA-5ygeA:
undetectable
2qwxB-5ygeA:
undetectable		 2qwxA-5ygeA:
20.37
2qwxB-5ygeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5yge AMINO-ACID
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 161
ARG A 111
VAL A 112
 None
 0.88A 4x3uA-5ygeA:
undetectable
4x3uB-5ygeA:
undetectable		 4x3uA-5ygeA:
19.01
4x3uB-5ygeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5yge AMINO-ACID
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 100
ALA A 104
LEU A 107
LEU A 174
 None
 0.86A 5vkqA-5ygeA:
undetectable
5vkqD-5ygeA:
undetectable		 5vkqA-5ygeA:
7.95
5vkqD-5ygeA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5yge AMINO-ACID
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 174
LEU A 100
ALA A 104
LEU A 107
 None
 0.83A 5vkqB-5ygeA:
undetectable
5vkqC-5ygeA:
undetectable		 5vkqB-5ygeA:
7.95
5vkqC-5ygeA:
7.95