SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ygu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		3 / 3 ASP A  57
ASP A  53
ASP A  94
 None
 0.65A 1eizA-5yguA:
undetectable		 1eizA-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		3 / 3 ASP A  57
ASP A  53
ASP A  94
 None
 0.65A 1ej0A-5yguA:
undetectable		 1ej0A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		3 / 3 MET A 118
ASN A  11
GLN A  44
 None
IOD  A 308 (-4.5A)
None
 0.71A 1xoqB-5yguA:
undetectable		 1xoqB-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		4 / 5 ALA A  65
ILE A  30
ASN A  64
ILE A  62
 None
 1.09A 2h4jA-5yguA:
undetectable		 2h4jA-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		3 / 3 ARG A  96
ASP A  53
ASP A  57
 None
 0.89A 3jb2A-5yguA:
undetectable		 3jb2A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		4 / 6 TYR A 139
GLY A 151
THR A 138
LEU A 149
 None
None
None
IOD  A 306 ( 4.4A)
 1.00A 3ps9A-5yguA:
undetectable		 3ps9A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		5 / 12 GLY A 218
ALA A 221
ILE A 202
GLY A 192
VAL A 240
 IOD  A 308 ( 3.7A)
None
None
None
None
 1.05A 3ucbA-5yguA:
undetectable		 3ucbA-5yguA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		5 / 12 VAL A 206
ASN A  11
GLN A  72
LEU A 247
ASN A 157
 None
IOD  A 308 (-4.5A)
TLA  A 301 (-3.2A)
None
TLA  A 301 (-3.4A)
 1.37A 4kuoA-5yguA:
undetectable		 4kuoA-5yguA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		5 / 12 ALA A  81
GLU A  49
LEU A  46
ILE A  62
CYH A  73
 None
 1.34A 5vlmA-5yguA:
undetectable		 5vlmA-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		4 / 8 ILE A  62
PHE A  25
LEU A  33
ALA A  34
 None
 0.88A 5y7pC-5yguA:
undetectable		 5y7pC-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5ygu DIAMINOPIMELATE
EPIMERASE
(Escherichia
coli) 		3 / 3 ALA A  77
PHE A  13
GLN A  44
 None
 0.78A 6eceA-5yguA:
undetectable		 6eceA-5yguA:
undetectable