SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5yh0 DRFAM20C1
(Danio
rerio) 		5 / 12 LEU A 297
LEU A 487
ARG A 301
LEU A 470
VAL A 532
 None
 1.33A 2qd4A-5yh0A:
undetectable		 2qd4A-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5yh0 DRFAM20C1
(Danio
rerio) 		4 / 4 LEU A 453
ALA A 365
VAL A 305
PRO A 304
 None
 1.15A 3gv1B-5yh0A:
undetectable		 3gv1B-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5yh0 DRFAM20C1
(Danio
rerio) 		4 / 8 SER A 344
ARG A 435
GLY A 456
ARG A 457
 None
 0.96A 4fgzA-5yh0A:
undetectable
4fgzB-5yh0A:
undetectable		 4fgzA-5yh0A:
undetectable
4fgzB-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5yh0 DRFAM20C1
(Danio
rerio) 		3 / 3 PRO A 143
LEU A 144
GLN A 553
 None
 0.73A 4pevB-5yh0A:
undetectable		 4pevB-5yh0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5yh0 DRFAM20C1
(Danio
rerio) 		5 / 11 PHE A 299
GLY A 431
PHE A 459
ALA A 290
ASP A 294
 None
 1.20A 4wnuC-5yh0A:
undetectable		 4wnuC-5yh0A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5yh0 DRFAM20C1
(Danio
rerio) 		5 / 10 PHE A 299
GLY A 431
PHE A 459
ALA A 290
ASP A 294
 None
 1.24A 4wnuD-5yh0A:
undetectable		 4wnuD-5yh0A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5yh0 DRFAM20C1
(Danio
rerio) 		4 / 6 LEU A 246
LYS A 261
PRO A 262
GLU A 282
 None
 1.17A 4z4gA-5yh0A:
undetectable		 4z4gA-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yh0 DRFAM20C1
(Danio
rerio) 		5 / 12 ALA A 290
THR A 271
GLN A 269
PHE A 459
THR A 266
 None
 1.21A 5hfjB-5yh0A:
undetectable		 5hfjB-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yh0 DRFAM20C1
(Danio
rerio) 		6 / 12 ALA A 290
THR A 271
GLN A 269
PHE A 459
THR A 266
GLU A 282
 None
 1.32A 5hfjC-5yh0A:
undetectable		 5hfjC-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yh0 DRFAM20C1
(Danio
rerio) 		6 / 12 ALA A 290
THR A 271
GLN A 269
PHE A 459
THR A 266
GLU A 282
 None
 1.36A 5hfjG-5yh0A:
undetectable		 5hfjG-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5yh0 DRFAM20C1
(Danio
rerio) 		3 / 3 LYS A 261
PRO A 262
LYS A 264
 None
 1.08A 5y9yA-5yh0A:
undetectable		 5y9yA-5yh0A:
undetectable