SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5yh1 -
(-) 		5 / 9 ASP A 366
ALA A 498
GLU A 504
VAL A 435
GLY A 367
 MN  A 805 (-3.1A)
MN  A 805 ( 4.6A)
None
None
None
 1.35A 1bcuH-5yh1A:
undetectable		 1bcuH-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5yh1 -
(-) 		5 / 11 LEU A 619
LEU A 736
VAL A 733
MET A 681
LEU A 664
 None
 1.35A 1kt6A-5yh1A:
undetectable		 1kt6A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5yh1 -
(-) 		5 / 11 LEU A 619
LEU A 736
VAL A 733
MET A 681
LEU A 664
 None
 1.32A 1kt7A-5yh1A:
undetectable		 1kt7A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 5yh1 -
(-) 		4 / 5 SER A 401
ARG A 360
HIS A 462
HIS A 463
 None
None
MN  A 805 (-3.6A)
None
 1.42A 1s19A-5yh1A:
undetectable		 1s19A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5yh1 -
(-) 		5 / 12 LEU A 359
ALA A 344
ILE A 347
ILE A 509
ALA A 506
 None
 0.96A 2bxcA-5yh1A:
undetectable		 2bxcA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5yh1 -
(-) 		5 / 10 ILE A 575
ARG A 398
ILE A 517
GLU A 576
ILE A 581
 None
 1.20A 2dm6A-5yh1A:
undetectable
2dm6B-5yh1A:
2.2		 2dm6A-5yh1A:
undetectable
2dm6B-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5yh1 -
(-) 		5 / 12 GLY A 499
GLY A 525
GLY A 527
THR A 497
LEU A 496
 None
 0.86A 2oxtB-5yh1A:
undetectable		 2oxtB-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5yh1 -
(-) 		4 / 5 HIS A 462
HIS A 463
ASP A 528
ASP A 364
 MN  A 805 (-3.6A)
None
MN  A 805 (-2.6A)
MN  A 805 ( 4.7A)
 1.17A 3c0zA-5yh1A:
3.3		 3c0zA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5yh1 -
(-) 		4 / 5 HIS A 463
ASP A 436
HIS A 462
ASP A 366
 None
MN  A 805 (-2.5A)
MN  A 805 (-3.6A)
MN  A 805 (-3.1A)
 1.18A 3c0zA-5yh1A:
3.3		 3c0zA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5yh1 -
(-) 		4 / 6 HIS A 462
HIS A 463
ASP A 528
ASP A 364
 MN  A 805 (-3.6A)
None
MN  A 805 (-2.6A)
MN  A 805 ( 4.7A)
 1.18A 3c0zC-5yh1A:
undetectable		 3c0zC-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5yh1 -
(-) 		5 / 12 ILE A 581
THR A 376
THR A 582
ILE A 578
ILE A 575
 None
 1.19A 3kpdB-5yh1A:
undetectable		 3kpdB-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5yh1 -
(-) 		4 / 8 PHE A 396
ILE A 357
ALA A 377
VAL A 433
 None
 0.80A 3me6B-5yh1A:
undetectable		 3me6B-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5yh1 -
(-) 		5 / 12 TYR A 538
LEU A 496
VAL A 489
HIS A 488
HIS A 483
 None
 1.31A 3vt7A-5yh1A:
undetectable		 3vt7A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5yh1 -
(-) 		5 / 12 GLY A 525
ASP A 364
ASP A 436
HIS A 462
GLY A 367
 None
MN  A 805 ( 4.7A)
MN  A 805 (-2.5A)
MN  A 805 (-3.6A)
None
 1.10A 4bz6C-5yh1A:
undetectable		 4bz6C-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5yh1 -
(-) 		4 / 8 VAL A 476
HIS A 463
ASN A 437
HIS A 483
 None
 0.91A 4exsB-5yh1A:
undetectable		 4exsB-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5yh1 -
(-) 		5 / 12 ILE A 379
ILE A 517
VAL A 435
LEU A 359
ILE A 378
 None
 0.82A 4km2B-5yh1A:
undetectable		 4km2B-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5yh1 -
(-) 		4 / 7 LEU A 333
VAL A 332
PRO A 486
GLU A 504
 None
 0.97A 4lb2A-5yh1A:
undetectable		 4lb2A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5yh1 -
(-) 		3 / 3 LYS A 397
ARG A 398
HIS A 361
 None
 1.26A 4zbrA-5yh1A:
undetectable		 4zbrA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5yh1 -
(-) 		4 / 6 GLU A 549
GLY A 367
ASP A 364
GLY A 499
 None
None
MN  A 805 ( 4.7A)
None
 0.97A 5cdpA-5yh1A:
3.4
5cdpB-5yh1A:
3.0		 5cdpA-5yh1A:
undetectable
5cdpB-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5yh1 -
(-) 		5 / 12 ASP A 679
HIS A 463
ASP A 436
HIS A 462
ASP A 366
 None
None
MN  A 805 (-2.5A)
MN  A 805 (-3.6A)
MN  A 805 (-3.1A)
 1.41A 5ef8A-5yh1A:
3.3		 5ef8A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5yh1 -
(-) 		5 / 12 ASP A 679
HIS A 463
ASP A 436
HIS A 462
ASP A 366
 None
None
MN  A 805 (-2.5A)
MN  A 805 (-3.6A)
MN  A 805 (-3.1A)
 1.42A 5ef8B-5yh1A:
3.4		 5ef8B-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5yh1 -
(-) 		5 / 12 ARG A 507
GLY A 367
ILE A 340
ALA A 344
GLY A 371
 None
 0.98A 5veuH-5yh1A:
undetectable		 5veuH-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5yh1 -
(-) 		4 / 7 ALA A 370
THR A 369
TYR A 368
VAL A 435
 None
 0.96A 6cduA-5yh1A:
undetectable
6cduE-5yh1A:
undetectable		 6cduA-5yh1A:
undetectable
6cduE-5yh1A:
undetectable