SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 12 LEU C 377
ILE C 384
GLY C 386
PHE C 284
GLY C 480
 None
 1.10A 1zz1C-5yh3C:
undetectable		 1zz1C-5yh3C:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 4 LEU C 477
ALA C 389
VAL C 329
PRO C 328
 None
 1.08A 3gv1B-5yh3C:
undetectable		 3gv1B-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 5 ASP C 422
GLU C 427
TYR C 425
GLU C 418
 None
 1.45A 3w9tA-5yh3C:
undetectable		 3w9tA-5yh3C:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 5 ASP C 422
GLU C 427
TYR C 425
GLU C 418
 None
 1.46A 3w9tC-5yh3C:
undetectable		 3w9tC-5yh3C:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 5 ASP C 422
GLU C 427
TYR C 425
GLU C 418
 None
 1.44A 3w9tD-5yh3C:
0.0		 3w9tD-5yh3C:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 5 ASP C 422
GLU C 427
TYR C 425
GLU C 418
 None
 1.46A 3w9tG-5yh3C:
0.0		 3w9tG-5yh3C:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 8 SER C 368
ARG C 459
GLY C 480
ARG C 481
 None
 1.03A 4fgzA-5yh3C:
undetectable
4fgzB-5yh3C:
undetectable		 4fgzA-5yh3C:
undetectable
4fgzB-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 4 ILE C 441
SER C 438
ASP C 446
ASP C 318
 None
 1.36A 4krhB-5yh3C:
undetectable		 4krhB-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 12 ASN C 479
GLY C 482
LEU C 546
ARG C 549
MET C 525
 None
 1.47A 4p6xG-5yh3C:
undetectable		 4p6xG-5yh3C:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 11 PHE C 323
GLY C 455
PHE C 483
ALA C 314
ASP C 318
 None
 1.23A 4wnuC-5yh3C:
undetectable		 4wnuC-5yh3C:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 10 PHE C 323
GLY C 455
PHE C 483
ALA C 314
ASP C 318
 None
 1.26A 4wnuD-5yh3C:
undetectable		 4wnuD-5yh3C:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 6 ARG C 502
ARG C 504
ASP C 573
VAL C 569
 None
 1.38A 4xqeA-5yh3C:
undetectable		 4xqeA-5yh3C:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 6 ARG C 502
ARG C 504
ASP C 573
VAL C 569
 None
 1.39A 4xqeB-5yh3C:
undetectable		 4xqeB-5yh3C:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 12 ALA C 314
THR C 295
GLN C 293
PHE C 483
THR C 290
 None
 1.34A 5hfjC-5yh3C:
undetectable		 5hfjC-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		5 / 12 ASP C 318
ASP C 458
GLN C 269
GLY C 480
GLU C 311
 None
 1.17A 5hfjF-5yh3C:
undetectable		 5hfjF-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 7 PHE C 276
SER C 260
VAL C 343
ARG C 332
 None
 1.41A 6av6C-5yh3C:
undetectable
6av6D-5yh3C:
undetectable		 6av6C-5yh3C:
25.26
6av6D-5yh3C:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens) 		4 / 6 GLN C 293
GLU C 294
HIS C 542
GLN C 289
 None
 1.42A 6f6jC-5yh3C:
undetectable
6f6jD-5yh3C:
undetectable		 6f6jC-5yh3C:
undetectable
6f6jD-5yh3C:
undetectable