SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 LYS A  88
LYS A  89
ASP A  92
ALA A  93
 None
 0.23A 1iwhA-5yh5A:
undetectable		 1iwhA-5yh5A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.11A 1p6kA-5yh5A:
undetectable		 1p6kA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.17A 1p6kB-5yh5A:
undetectable		 1p6kB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.15A 1rs6A-5yh5A:
undetectable		 1rs6A-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.23A 1rs6B-5yh5A:
undetectable		 1rs6B-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_EDTA1513_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 9 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 1zlqA-5yh5A:
43.3		 1zlqA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 8 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 1zlqB-5yh5A:
30.4		 1zlqB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.15A 1zzqA-5yh5A:
undetectable		 1zzqA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.20A 1zzqB-5yh5A:
undetectable		 1zzqB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.14A 1zzuA-5yh5A:
undetectable		 1zzuA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.16A 1zzuB-5yh5A:
undetectable		 1zzuB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 SER A 261
VAL A 268
PHE A 372
ARG A 274
ILE A 277
 None
 1.20A 2vdyA-5yh5A:
undetectable		 2vdyA-5yh5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 SER A 261
VAL A 268
PHE A 372
ARG A 274
ILE A 277
 None
 1.22A 2vdyB-5yh5A:
undetectable		 2vdyB-5yh5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 10 ILE A 465
THR A 429
ILE A 416
ILE A 442
SER A 441
 None
 1.46A 3kpbD-5yh5A:
undetectable		 3kpbD-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.22A 3n62A-5yh5A:
undetectable		 3n62A-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.17A 3n62B-5yh5A:
undetectable		 3n62B-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.22A 3n66B-5yh5A:
undetectable		 3n66B-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 10 ILE A 442
ALA A 418
SER A 430
SER A 261
ILE A 432
 None
 1.26A 3qgtA-5yh5A:
undetectable		 3qgtA-5yh5A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 501
PHE A 221
ALA A 199
THR A  15
 None
 0.99A 3t3sE-5yh5A:
undetectable		 3t3sE-5yh5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		3 / 3 TYR A 353
MET A 352
ILE A 472
 None
 0.88A 4c8bB-5yh5A:
undetectable		 4c8bB-5yh5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 10 VAL A 482
ASP A 228
SER A 234
VAL A 246
THR A 222
 None
 1.44A 4eilD-5yh5A:
undetectable		 4eilD-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.22A 4kcnB-5yh5A:
undetectable		 4kcnB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OES_A_EDTA601_0
(NIKA PROTEIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 6 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.62A 4oesA-5yh5A:
44.5		 4oesA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 ASP A 443
TYR A 458
PRO A 412
LEU A 462
 None
 1.32A 5bmvB-5yh5A:
undetectable		 5bmvB-5yh5A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 TYR A 410
GLN A 413
ALA A 137
ALA A 134
TYR A 497
 None
 1.22A 5cxvA-5yh5A:
undetectable		 5cxvA-5yh5A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 8 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 5l8dA-5yh5A:
30.7		 5l8dA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 8 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 5mwuA-5yh5A:
30.7		 5mwuA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A 281
ALA A 330
LEU A 379
LEU A 400
VAL A 259
 None
 1.09A 5tudA-5yh5A:
3.8		 5tudA-5yh5A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.21A 5vunA-5yh5A:
undetectable		 5vunA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.24A 5vunB-5yh5A:
undetectable		 5vunB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.24A 5vuoB-5yh5A:
undetectable		 5vuoB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 GLY A 166
TYR A  38
LEU A  52
VAL A  74
 None
 0.90A 5x80A-5yh5A:
undetectable
5x80B-5yh5A:
undetectable		 5x80A-5yh5A:
18.25
5x80B-5yh5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.25A 6auuB-5yh5A:
undetectable		 6auuB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 VAL A 258
PRO A 473
ALA A 428
THR A 429
 None
 1.05A 6cduB-5yh5A:
undetectable
6cduC-5yh5A:
undetectable		 6cduB-5yh5A:
undetectable
6cduC-5yh5A:
undetectable