SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.76A 1nsiA-5yhhA:
undetectable
1nsiB-5yhhA:
undetectable		 1nsiA-5yhhA:
11.96
1nsiB-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.78A 1nsiA-5yhhA:
undetectable
1nsiB-5yhhA:
undetectable		 1nsiA-5yhhA:
11.96
1nsiB-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.83A 1nsiC-5yhhA:
undetectable
1nsiD-5yhhA:
undetectable		 1nsiC-5yhhA:
11.96
1nsiD-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.75A 1nsiC-5yhhA:
undetectable
1nsiD-5yhhA:
undetectable		 1nsiC-5yhhA:
11.96
1nsiD-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 154
TRP A  87
MET A   1
GLY A 156
 None
 1.25A 2hs1B-5yhhA:
undetectable		 2hs1B-5yhhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.79A 2nsiA-5yhhA:
undetectable
2nsiB-5yhhA:
undetectable		 2nsiA-5yhhA:
11.96
2nsiB-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.81A 2nsiA-5yhhA:
undetectable
2nsiB-5yhhA:
undetectable		 2nsiA-5yhhA:
11.96
2nsiB-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.81A 2nsiC-5yhhA:
undetectable
2nsiD-5yhhA:
undetectable		 2nsiC-5yhhA:
11.96
2nsiD-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.79A 2nsiC-5yhhA:
undetectable
2nsiD-5yhhA:
undetectable		 2nsiC-5yhhA:
11.96
2nsiD-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.78A 3e7gA-5yhhA:
undetectable
3e7gB-5yhhA:
undetectable		 3e7gA-5yhhA:
11.33
3e7gB-5yhhA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.78A 3e7gA-5yhhA:
undetectable
3e7gB-5yhhA:
undetectable		 3e7gA-5yhhA:
11.33
3e7gB-5yhhA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.80A 3e7gC-5yhhA:
undetectable
3e7gD-5yhhA:
undetectable		 3e7gC-5yhhA:
11.33
3e7gD-5yhhA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.82A 3e7gC-5yhhA:
undetectable
3e7gD-5yhhA:
undetectable		 3e7gC-5yhhA:
11.33
3e7gD-5yhhA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 106
ALA A 108
VAL A 147
ILE A   6
VAL A 110
 None
 0.89A 3el5B-5yhhA:
undetectable		 3el5B-5yhhA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 LYS A 140
PHE A  83
PHE A  78
TYR A  74
 None
 1.29A 3elzB-5yhhA:
undetectable		 3elzB-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.77A 4cx7A-5yhhA:
undetectable
4cx7B-5yhhA:
undetectable		 4cx7A-5yhhA:
11.96
4cx7B-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.75A 4cx7A-5yhhA:
undetectable
4cx7B-5yhhA:
undetectable		 4cx7A-5yhhA:
11.96
4cx7B-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.81A 4cx7C-5yhhA:
undetectable
4cx7D-5yhhA:
undetectable		 4cx7C-5yhhA:
11.96
4cx7D-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.80A 4cx7C-5yhhA:
undetectable
4cx7D-5yhhA:
undetectable		 4cx7C-5yhhA:
11.96
4cx7D-5yhhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.82A 4nosA-5yhhA:
undetectable
4nosB-5yhhA:
undetectable		 4nosA-5yhhA:
11.24
4nosB-5yhhA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.79A 4nosC-5yhhA:
undetectable
4nosD-5yhhA:
undetectable		 4nosC-5yhhA:
11.24
4nosD-5yhhA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A  87
PHE A 145
GLU A  85
ILE A   3
 None
 0.81A 4nosC-5yhhA:
undetectable
4nosD-5yhhA:
undetectable		 4nosC-5yhhA:
11.24
4nosD-5yhhA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  26
LYS A 120
LEU A 131
 None
OCS  A 119 ( 3.1A)
None
 1.08A 4ptjA-5yhhA:
undetectable		 4ptjA-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 128
TYR A  74
ALA A 134
ILE A 135
 None
 1.20A 4y03B-5yhhA:
undetectable		 4y03B-5yhhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 163
GLY A 165
GLY A 100
ASP A 101
 None
 0.92A 5a06D-5yhhA:
undetectable		 5a06D-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 181
GLY A 165
ASP A 101
GLY A 167
 None
 0.98A 5cdpA-5yhhA:
undetectable
5cdpB-5yhhA:
undetectable		 5cdpA-5yhhA:
11.14
5cdpB-5yhhA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A  62
GLU A  85
GLY A  81
ALA A  80
PHE A 143
 None
 1.25A 5cprB-5yhhA:
undetectable		 5cprB-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A  65
PRO A  63
GLY A  91
PHE A 143
 None
 1.32A 5jcnB-5yhhA:
undetectable		 5jcnB-5yhhA:
undetectable