SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		5 / 10 VAL A 154
LEU A  39
LEU A  57
TYR A 146
ALA A 109
 None
 1.18A 1pbcA-5yhiA:
undetectable		 1pbcA-5yhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		4 / 7 TYR A  60
LEU A 123
ASN A 124
TYR A  65
 None
 1.42A 2w98A-5yhiA:
undetectable
2w98B-5yhiA:
undetectable		 2w98A-5yhiA:
12.78
2w98B-5yhiA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		5 / 12 VAL A 113
SER A 198
SER A 200
THR A 204
ALA A 194
 None
None
PO4  A 301 (-3.0A)
None
None
 1.04A 2x2iC-5yhiA:
undetectable		 2x2iC-5yhiA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		4 / 8 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.09A 2xytE-5yhiA:
undetectable		 2xytE-5yhiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		4 / 8 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.11A 2xytH-5yhiA:
undetectable		 2xytH-5yhiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		4 / 7 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.11A 2xytI-5yhiA:
undetectable		 2xytI-5yhiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		5 / 12 LEU A 191
LEU A 197
ALA A 175
VAL A 113
HIS A  64
 None
 1.29A 3b0wA-5yhiA:
undetectable		 3b0wA-5yhiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		3 / 3 PHE A  84
TYR A  67
LEU A  88
 None
 0.73A 3keeB-5yhiA:
undetectable		 3keeB-5yhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		4 / 6 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.12A 3pmzD-5yhiA:
undetectable		 3pmzD-5yhiA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5yhi PROTEIN YIIM
(Escherichia
coli) 		5 / 10 LEU A 162
VAL A 166
VAL A 113
TYR A  99
GLY A 101
 None
 1.37A 6bsjA-5yhiA:
undetectable		 6bsjA-5yhiA:
22.58