SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yhj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 10 VAL A 384
TYR A 382
TYR A 283
LEU A 404
LEU A 369
 None
 1.29A 1mrlA-5yhjA:
0.0
1mrlC-5yhjA:
0.0		 1mrlA-5yhjA:
17.59
1mrlC-5yhjA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 11 ALA A 289
HIS A  92
GLY A 356
HIS A 357
GLY A 349
 HEM  A 501 ( 4.1A)
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
 0.96A 1pg2A-5yhjA:
undetectable		 1pg2A-5yhjA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		3 / 3 PHE A 250
TYR A  22
TYR A 315
 None
 1.03A 1x70B-5yhjA:
undetectable		 1x70B-5yhjA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		3 / 3 GLN A 371
THR A 241
TRP A 146
 None
HEM  A 501 (-3.4A)
None
 0.48A 2rctA-5yhjA:
undetectable		 2rctA-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 11 ALA A 289
HIS A  92
GLY A 356
HIS A 357
GLY A 349
 HEM  A 501 ( 4.1A)
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
 1.02A 2x1lA-5yhjA:
undetectable		 2x1lA-5yhjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 ALA A 289
HIS A  92
GLY A 356
HIS A 357
GLY A 349
 HEM  A 501 ( 4.1A)
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
 1.06A 2x1lB-5yhjA:
undetectable		 2x1lB-5yhjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 11 ALA A 289
HIS A  92
GLY A 356
HIS A 357
GLY A 349
 HEM  A 501 ( 4.1A)
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
 1.06A 2x1lC-5yhjA:
undetectable		 2x1lC-5yhjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 LEU A 235
VAL A 232
THR A 241
VAL A 364
ASN A 107
 None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.4A)
None
 1.36A 2y00B-5yhjA:
undetectable		 2y00B-5yhjA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 LEU A 235
VAL A 232
THR A 241
VAL A 364
ASN A 107
 None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.4A)
None
 1.36A 2y01B-5yhjA:
undetectable		 2y01B-5yhjA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 ILE A 368
THR A 115
THR A 241
ASN A 107
ILE A 108
 None
None
HEM  A 501 (-3.4A)
None
None
 1.08A 3kpdB-5yhjA:
undetectable		 3kpdB-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		4 / 8 PHE A  79
ALA A  70
ALA A 290
LEU A 314
 None
None
None
HEM  A 501 (-4.9A)
 0.92A 3l4dD-5yhjA:
32.1		 3l4dD-5yhjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		4 / 7 VAL A 230
VAL A  84
ILE A 237
ARG A 218
 None
HEM  A 501 (-3.9A)
HEM  A 501 ( 4.6A)
None
 0.99A 3mssB-5yhjA:
undetectable		 3mssB-5yhjA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 ASP A 320
ARG A  29
THR A 317
PHE A 304
ALA A 303
 None
 1.12A 3ua1A-5yhjA:
23.4		 3ua1A-5yhjA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 5 LEU A  78
PHE A 167
ARG A 239
PRO A 240
ALA A 243
 None
None
MYR  A 502 (-4.2A)
MYR  A 502 ( 3.7A)
MYR  A 502 (-3.7A)
 0.49A 3vm4A-5yhjA:
58.4		 3vm4A-5yhjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 PHE A  79
PRO A  71
LEU A  42
VAL A  46
ALA A 289
 None
None
None
None
HEM  A 501 ( 4.1A)
 1.32A 4a84A-5yhjA:
undetectable		 4a84A-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		4 / 5 ARG A 159
MET A 163
GLU A 162
LEU A 235
 None
 1.24A 4hojA-5yhjA:
undetectable		 4hojA-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		4 / 5 TYR A 382
LEU A 389
PRO A 385
LEU A 249
 None
 1.35A 5eshA-5yhjA:
27.3		 5eshA-5yhjA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 GLN A   8
PHE A  37
LEU A 311
VAL A 288
GLY A  21
 None
 1.13A 5i8fA-5yhjA:
undetectable		 5i8fA-5yhjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		6 / 10 PRO A  71
LEU A  78
ARG A 239
PRO A 240
ALA A 243
PHE A 285
 None
None
MYR  A 502 (-4.2A)
MYR  A 502 ( 3.7A)
MYR  A 502 (-3.7A)
HEM  A 501 ( 3.9A)
 0.66A 5m0oA-5yhjA:
55.8		 5m0oA-5yhjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 8 LEU A  78
ARG A 239
PRO A 240
ALA A 243
PHE A 285
 None
MYR  A 502 (-4.2A)
MYR  A 502 ( 3.7A)
MYR  A 502 (-3.7A)
HEM  A 501 ( 3.9A)
 0.44A 5m0oC-5yhjA:
55.1		 5m0oC-5yhjA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5yhj CYTOCHROME P450
(Exiguobacterium
sp.
AT1b) 		5 / 12 VAL A  46
LEU A 314
ASP A 313
PRO A  71
LEU A  74
 None
HEM  A 501 (-4.9A)
None
None
None
 1.40A 5syfB-5yhjA:
undetectable		 5syfB-5yhjA:
11.50