SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 ASP A 212
ARG A 208
ILE A 300
None
0.87A 1a4gB-5yhpA:
undetectable
1a4gB-5yhpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 TRP A 105
ALA A 126
VAL A 128
None
0.93A 1c4dC-5yhpA:
undetectable
1c4dD-5yhpA:
undetectable
1c4dC-5yhpA:
5.95
1c4dD-5yhpA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 GLY A  42
GLY A  43
SER A 111
PHE A 236
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
0.93A 1dx6A-5yhpA:
12.7
1dx6A-5yhpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 GLY A 113
GLY A  42
GLY A  43
SER A 111
HIS A 297
None
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
FLC  A 402 (-3.7A)
1.00A 1dx6A-5yhpA:
12.7
1dx6A-5yhpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
4 / 8 TYR A  61
SER A   3
LEU A   4
GLU A 305
None
0.88A 1eupA-5yhpA:
undetectable
1eupA-5yhpA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
None
1.12A 1fe2A-5yhpA:
undetectable
1fe2A-5yhpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
None
1.10A 1igxA-5yhpA:
undetectable
1igxA-5yhpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 10 GLU A 143
ARG A 140
ALA A 277
PHE A 137
GLY A 110
None
1.27A 1mjqG-5yhpA:
undetectable
1mjqH-5yhpA:
undetectable
1mjqG-5yhpA:
14.33
1mjqH-5yhpA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 GLY A  42
GLY A  43
SER A 111
PHE A 236
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
0.85A 1qtiA-5yhpA:
11.6
1qtiA-5yhpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 11 GLY A  42
GLY A  43
SER A 111
PHE A 228
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
1.04A 1w76A-5yhpA:
12.0
1w76A-5yhpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 10 GLY A  42
GLY A  43
SER A 111
PHE A 236
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
0.83A 1w76B-5yhpA:
12.1
1w76B-5yhpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
4 / 6 HIS A  41
TYR A 235
ARG A  69
GLY A  70
None
1.38A 2i30A-5yhpA:
undetectable
2i30A-5yhpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 TYR A  61
GLY A  30
PHE A  56
None
0.70A 2m2pB-5yhpA:
undetectable
2m2pB-5yhpA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 GLU A 162
LEU A 165
ASP A 166
None
0.33A 3ko0A-5yhpA:
undetectable
3ko0A-5yhpA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 GLU A 162
LEU A 165
ASP A 166
None
0.23A 3ko0T-5yhpA:
undetectable
3ko0T-5yhpA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
4 / 6 GLY A  42
GLY A  43
SER A 111
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
FLC  A 402 (-3.7A)
0.81A 3o9mB-5yhpA:
12.8
3o9mB-5yhpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 LEU A 131
ILE A 136
ALA A 123
LEU A 280
LEU A 139
None
1.23A 3vw1B-5yhpA:
undetectable
3vw1B-5yhpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
None
1.06A 4e1gA-5yhpA:
undetectable
4e1gA-5yhpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
None
1.07A 4e1gB-5yhpA:
undetectable
4e1gB-5yhpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 PHE A 315
LEU A 118
ILE A 136
ALA A 277
THR A 281
None
0.95A 4enhA-5yhpA:
undetectable
4enhA-5yhpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 GLY A  42
GLY A  43
SER A 111
PHE A 236
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
0.86A 4ey6A-5yhpA:
13.0
4ey6A-5yhpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 GLY A  42
GLY A  43
SER A 111
PHE A 236
HIS A 297
FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
None
FLC  A 402 (-3.7A)
0.86A 4ey6B-5yhpA:
11.3
4ey6B-5yhpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.90A 4k8cA-5yhpA:
undetectable
4k8cA-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.91A 4kahA-5yhpA:
undetectable
4kahA-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.90A 4kahB-5yhpA:
undetectable
4kahB-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.92A 4kanA-5yhpA:
undetectable
4kanA-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.91A 4kanB-5yhpA:
undetectable
4kanB-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.90A 4kbeA-5yhpA:
undetectable
4kbeA-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.87A 4kbeB-5yhpA:
undetectable
4kbeB-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.92A 4lbgA-5yhpA:
undetectable
4lbgA-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 SER A 233
TYR A 181
PRO A  44
None
0.92A 4lbgB-5yhpA:
undetectable
4lbgB-5yhpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 11 ALA A  87
ASP A  82
SER A  71
ILE A 231
ARG A 230
None
None
None
None
FLC  A 401 (-3.6A)
1.16A 4qi9C-5yhpA:
undetectable
4qi9C-5yhpA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 9 THR A 115
ALA A 277
GLY A 113
GLY A 110
ASP A 269
None
1.16A 4qwuK-5yhpA:
undetectable
4qwuL-5yhpA:
undetectable
4qwuK-5yhpA:
22.94
4qwuL-5yhpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 9 THR A 115
ALA A 277
GLY A 113
GLY A 110
ASP A 269
None
1.12A 4qwuY-5yhpA:
undetectable
4qwuZ-5yhpA:
undetectable
4qwuY-5yhpA:
22.94
4qwuZ-5yhpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 12 VAL A 271
GLU A 232
GLY A  43
ILE A 231
SER A  71
None
None
FLC  A 402 (-3.4A)
None
None
1.43A 4xudA-5yhpA:
2.7
4xudA-5yhpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
4 / 7 LEU A 139
GLU A 244
GLY A 239
GLY A 240
None
0.75A 5a06B-5yhpA:
3.7
5a06B-5yhpA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
4 / 5 HIS A 297
SER A 111
GLN A 265
ILE A 136
FLC  A 402 (-3.7A)
FLC  A 402 (-2.5A)
None
None
1.43A 5fuqA-5yhpA:
2.0
5fuqB-5yhpA:
undetectable
5fuqA-5yhpA:
20.60
5fuqB-5yhpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 THR A  13
PRO A  10
ASP A  50
None
0.55A 5l8dB-5yhpA:
undetectable
5l8dB-5yhpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
3 / 3 THR A  13
PRO A  10
ASP A  50
None
0.55A 5mwuB-5yhpA:
undetectable
5mwuB-5yhpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica)
5 / 9 LEU A  40
VAL A  89
ILE A 256
LEU A 133
ALA A 123
None
1.33A 5og9A-5yhpA:
undetectable
5og9A-5yhpA:
20.49