SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  64
VAL A  82
TRP A  80
 None
 0.86A 1av2A-5yhtA:
undetectable
1av2B-5yhtA:
undetectable		 1av2A-5yhtA:
undetectable
1av2B-5yhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 190
TRP A 124
GLU A 198
 None
 1.03A 1mogA-5yhtA:
undetectable		 1mogA-5yhtA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 201
VAL A 196
PHE A 159
ARG A 227
 None
 1.23A 3bjwH-5yhtA:
1.7		 3bjwH-5yhtA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 201
VAL A 196
PHE A 159
ARG A 227
 None
 1.34A 3bjwB-5yhtA:
1.8		 3bjwB-5yhtA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 244
THR A 245
ALA A 204
GLY A 225
ALA A 197
 None
 1.12A 4qvnK-5yhtA:
undetectable
4qvnL-5yhtA:
undetectable		 4qvnK-5yhtA:
17.22
4qvnL-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 244
THR A 245
ALA A 204
GLY A 225
ALA A 197
 None
 1.12A 4qvnY-5yhtA:
undetectable
4qvnZ-5yhtA:
undetectable		 4qvnY-5yhtA:
17.22
4qvnZ-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 244
THR A 245
ALA A 204
GLY A 225
ALA A 197
 None
 1.11A 4qvqK-5yhtA:
undetectable
4qvqL-5yhtA:
undetectable		 4qvqK-5yhtA:
15.38
4qvqL-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 244
THR A 245
ALA A 204
GLY A 225
ALA A 197
 None
 1.11A 4qvqY-5yhtA:
undetectable
4qvqZ-5yhtA:
undetectable		 4qvqY-5yhtA:
15.38
4qvqZ-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 204
ALA A 242
ALA A 244
VAL A 201
GLY A 188
 None
 0.92A 4qvyK-5yhtA:
undetectable
4qvyL-5yhtA:
undetectable		 4qvyK-5yhtA:
15.38
4qvyL-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 204
ALA A 242
ALA A 244
VAL A 201
GLY A 188
 None
 0.92A 4qvyY-5yhtA:
undetectable
4qvyZ-5yhtA:
undetectable		 4qvyY-5yhtA:
15.38
4qvyZ-5yhtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5yht HISTIDINOL-PHOSPHATA
SE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  17
SER A 100
PRO A  84
TRP A  80
 None
 1.17A 4uhxA-5yhtA:
undetectable		 4uhxA-5yhtA:
4.73