SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens) 		4 / 6 LEU A 355
LEU A 363
PRO A 364
MET A 365
 None
 0.95A 1hz4A-5yhuA:
undetectable		 1hz4A-5yhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens) 		5 / 10 VAL A 395
GLY A 375
ILE A 518
LEU A 495
PHE A 472
 None
 1.08A 1z11D-5yhuA:
undetectable		 1z11D-5yhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens) 		5 / 12 ILE A 438
VAL A 497
ILE A 399
VAL A 397
VAL A 395
 None
 1.18A 3iw1A-5yhuA:
undetectable		 3iw1A-5yhuA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens) 		4 / 8 LEU A 424
VAL A 370
VAL A 465
LEU A 495
 None
 1.02A 3v81C-5yhuA:
undetectable		 3v81C-5yhuA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens) 		4 / 8 PRO A 405
PHE A 420
LEU A 510
LEU A 417
 None
 0.89A 4qopC-5yhuA:
undetectable		 4qopC-5yhuA:
13.38