SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5yix RNA POLYMERASE SIGMA
FACTOR RPOD
(Caulobacter
vibrioides) 		4 / 7 PHE A 459
PHE A 467
ALA A 138
ILE A 141
 None
 1.01A 1fxhA-5yixA:
undetectable
1fxhB-5yixA:
undetectable		 1fxhA-5yixA:
undetectable
1fxhB-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5yix RNA POLYMERASE SIGMA
FACTOR RPOD
(Caulobacter
vibrioides) 		4 / 6 ARG A 145
ASP A 457
GLN A 477
GLU A 183
 None
 1.37A 2ya7C-5yixA:
undetectable		 2ya7C-5yixA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5yix RNA POLYMERASE SIGMA
FACTOR RPOD
(Caulobacter
vibrioides) 		4 / 8 ASP A 266
GLN A 265
GLU A 259
GLU A 160
 None
 1.11A 3dh0A-5yixA:
undetectable		 3dh0A-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5yix RNA POLYMERASE SIGMA
FACTOR RPOD
(Caulobacter
vibrioides) 		4 / 5 ALA A 415
GLU A 411
ALA A 143
MET A 148
 None
 1.31A 3r9tC-5yixA:
undetectable		 3r9tC-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 5yix RNA POLYMERASE SIGMA
FACTOR RPOD
(Caulobacter
vibrioides) 		4 / 7 LYS A 458
ALA A 193
TRP A 474
ALA A 187
 None
 1.25A 3tx2A-5yixA:
undetectable		 3tx2A-5yixA:
undetectable