SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A  94
VAL A 264
TRP A 266
 None
 1.20A 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable		 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 266
VAL A  93
TRP A  94
 None
 1.43A 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable		 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifA-5yj6A:
undetectable		 1kifA-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifB-5yj6A:
undetectable		 1kifB-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.33A 1kifC-5yj6A:
undetectable		 1kifC-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifD-5yj6A:
undetectable		 1kifD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifE-5yj6A:
undetectable		 1kifE-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifF-5yj6A:
undetectable		 1kifF-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifG-5yj6A:
undetectable		 1kifG-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.33A 1kifH-5yj6A:
undetectable		 1kifH-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A 367
VAL A 359
TRP A 358
 None
 0.89A 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable		 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 358
ALA A 367
VAL A 359
 None
 0.89A 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable		 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 358
ALA A 367
VAL A 359
 None
 0.89A 1kqeA-5yj6A:
undetectable
1kqeE-5yj6A:
undetectable		 1kqeA-5yj6A:
undetectable
1kqeE-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 390
TYR A 421
LEU A 323
 None
 0.86A 1kxhA-5yj6A:
undetectable		 1kxhA-5yj6A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 350
GLY A 400
ASP A 255
GLY A 441
ASN A 529
 None
 0.89A 1n2xB-5yj6A:
undetectable		 1n2xB-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 375
ASP A 165
ASN A 134
 None
 0.91A 1nbhA-5yj6A:
undetectable		 1nbhA-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 375
ASP A 165
ASN A 134
 None
 0.90A 1nbhD-5yj6A:
undetectable		 1nbhD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 MET A 474
GLY A 396
GLN A 392
MET A 451
ILE A 477
 None
 1.15A 1p93D-5yj6A:
undetectable		 1p93D-5yj6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.10A 1tt0A-5yj6A:
undetectable		 1tt0A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.10A 1tt0B-5yj6A:
undetectable		 1tt0B-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.10A 1tt0C-5yj6A:
undetectable		 1tt0C-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.11A 1tt0D-5yj6A:
undetectable		 1tt0D-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1ve9A-5yj6A:
undetectable		 1ve9A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 297
GLU A  87
TYR A 431
 None
None
33O  A 801 (-4.5A)
 0.68A 1wsvA-5yj6A:
undetectable		 1wsvA-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE A 611
PHE A 584
TYR A  80
TYR A 192
 None
 1.33A 2aoxA-5yj6A:
undetectable		 2aoxA-5yj6A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 2du8G-5yj6A:
undetectable		 2du8G-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.29A 2du8J-5yj6A:
undetectable		 2du8J-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 413
TYR A 141
GLU A 144
HIS A 346
 None
 1.13A 2ha4A-5yj6A:
undetectable		 2ha4A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 THR A 515
ALA A 399
TYR A 425
ASN A 437
 None
 1.13A 2hzqA-5yj6A:
undetectable		 2hzqA-5yj6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 655
THR A 659
MET A 654
SER A  39
 None
 1.26A 2o5yH-5yj6A:
undetectable
2o5yL-5yj6A:
undetectable		 2o5yH-5yj6A:
19.44
2o5yL-5yj6A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 527
LEU A 556
ILE A 487
ALA A 560
PHE A 485
 None
 1.04A 2qb4A-5yj6A:
undetectable		 2qb4A-5yj6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 PRO A 488
ILE A 487
GLY A 518
LYS A 478
 None
 0.90A 2qeuA-5yj6A:
undetectable
2qeuC-5yj6A:
undetectable		 2qeuA-5yj6A:
undetectable
2qeuC-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A 527
LEU A 556
ILE A 487
ALA A 560
PHE A 485
 None
 0.98A 2qjuA-5yj6A:
undetectable		 2qjuA-5yj6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
 None
 1.19A 3a51A-5yj6A:
undetectable		 3a51A-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
 None
 1.23A 3a51B-5yj6A:
undetectable		 3a51B-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
 None
 1.23A 3a51D-5yj6A:
undetectable		 3a51D-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
 None
 1.22A 3a51E-5yj6A:
undetectable		 3a51E-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 HIS A 646
GLU A 647
HIS A 642
 None
 0.85A 3ba0A-5yj6A:
undetectable		 3ba0A-5yj6A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 TYR A 565
LEU A  43
GLU A  46
LEU A  47
LYS A  50
 None
 1.13A 3f78A-5yj6A:
undetectable		 3f78A-5yj6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 TYR A 565
LEU A  43
GLU A  46
LEU A  47
LYS A  50
 None
 1.16A 3f78B-5yj6A:
undetectable		 3f78B-5yj6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 527
LEU A 556
ILE A 487
ALA A 560
PHE A 485
 None
 0.97A 3gwwA-5yj6A:
undetectable		 3gwwA-5yj6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 GLN A 384
GLN A 352
GLY A 350
HIS A 348
 None
 1.48A 3huoA-5yj6A:
undetectable		 3huoA-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ARG A 259
ASP A 118
GLY A  64
THR A  84
 None
 1.09A 3k4vB-5yj6A:
undetectable		 3k4vB-5yj6A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.11A 3lskB-5yj6A:
undetectable		 3lskB-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.08A 3lskD-5yj6A:
undetectable		 3lskD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 MET A 474
GLY A 396
GLN A 392
MET A 451
ILE A 477
 None
 1.43A 3mneA-5yj6A:
undetectable		 3mneA-5yj6A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 HIS A 183
SER A  86
ASP A 297
THR A 251
 None
None
None
33O  A 801 ( 3.9A)
 1.49A 3okxA-5yj6A:
undetectable		 3okxA-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 327
ASP A 297
ASP A 255
 33O  A 801 (-4.4A)
None
None
 1.00A 3ou7B-5yj6A:
undetectable		 3ou7B-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A 111
VAL A 115
GLU A  96
 None
 0.63A 3v4tA-5yj6A:
undetectable
3v4tD-5yj6A:
undetectable		 3v4tA-5yj6A:
undetectable
3v4tD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A 205
THR A 217
HIS A  68
LEU A 185
 None
 1.06A 4pgfA-5yj6A:
undetectable		 4pgfA-5yj6A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 385
PHE A 355
GLU A 452
VAL A 450
THR A 457
 None
 1.31A 4q15A-5yj6A:
undetectable		 4q15A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ALA A 432
GLN A 587
ASP A 147
PRO A 148
 None
 1.11A 5c6pA-5yj6A:
undetectable		 5c6pA-5yj6A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 HIS A 346
SER A 345
ILE A 342
TYR A 302
 None
 1.32A 5fuqA-5yj6A:
undetectable
5fuqB-5yj6A:
undetectable		 5fuqA-5yj6A:
undetectable
5fuqB-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 264
ALA A  97
VAL A  93
GLY A 655
THR A 659
 None
 1.20A 5igiA-5yj6A:
undetectable		 5igiA-5yj6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A 165
PRO A 166
TYR A 317
ASN A 296
 None
 1.25A 5l1fC-5yj6A:
undetectable		 5l1fC-5yj6A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 532
THR A 533
ALA A 658
GLY A 655
ALA A 653
 None
 1.20A 5lf3H-5yj6A:
undetectable
5lf3I-5yj6A:
undetectable		 5lf3H-5yj6A:
13.48
5lf3I-5yj6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 532
THR A 533
ALA A 658
GLY A 655
ALA A 653
 None
 1.21A 5lf3V-5yj6A:
undetectable
5lf3W-5yj6A:
undetectable		 5lf3V-5yj6A:
13.48
5lf3W-5yj6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ARG A 578
GLU A 576
GLU A  76
ARG A 643
 None
None
33O  A 801 (-3.7A)
33O  A 801 ( 4.6A)
 1.29A 6fk2A-5yj6A:
undetectable		 6fk2A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 487
ALA A 560
ARG A 559
ASP A 482
 None
 1.04A 6hu9m-5yj6A:
undetectable
6hu9q-5yj6A:
undetectable		 6hu9m-5yj6A:
undetectable
6hu9q-5yj6A:
undetectable