SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5yje PROTEIN HIRA
(Homo
sapiens) 		4 / 5 LEU A 768
VAL A 759
CYH A 749
ALA A 742
 None
 1.07A 1mz9D-5yjeA:
undetectable		 1mz9D-5yjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5yje PROTEIN HIRA
(Homo
sapiens) 		4 / 4 LEU A 768
VAL A 759
CYH A 749
ALA A 742
 None
 0.98A 1mz9E-5yjeA:
undetectable		 1mz9E-5yjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5yje PROTEIN HIRA
(Homo
sapiens) 		4 / 6 PRO A 686
PHE A 760
ILE A 738
SER A 758
 None
 1.14A 1sbrA-5yjeA:
undetectable
1sbrB-5yjeA:
undetectable		 1sbrA-5yjeA:
16.58
1sbrB-5yjeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5yje PROTEIN HIRA
(Homo
sapiens) 		3 / 3 GLY A 784
TYR A 786
SER A 785
 None
 0.69A 2xatA-5yjeA:
undetectable		 2xatA-5yjeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5yje PROTEIN HIRA
(Homo
sapiens) 		5 / 11 ALA A 789
ILE A 777
LEU A 757
THR A 740
ALA A 751
 None
 1.21A 3kw2B-5yjeA:
undetectable		 3kw2B-5yjeA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5yje PROTEIN HIRA
(Homo
sapiens) 		5 / 12 LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
 None
 1.09A 3nt1A-5yjeA:
undetectable		 3nt1A-5yjeA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5yje PROTEIN HIRA
(Homo
sapiens) 		5 / 12 LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
 None
 1.08A 3nt1B-5yjeA:
undetectable		 3nt1B-5yjeA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yje PROTEIN HIRA
(Homo
sapiens) 		5 / 12 LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
 None
 1.00A 3rr3A-5yjeA:
undetectable		 3rr3A-5yjeA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yje PROTEIN HIRA
(Homo
sapiens) 		5 / 12 LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
 None
 1.00A 3rr3B-5yjeA:
undetectable		 3rr3B-5yjeA:
9.84