SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 ILE A 621
HIS A 500
LEU A 516
VAL A 535
 None
 0.81A 1fslB-5yjhA:
undetectable		 1fslB-5yjhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 7 VAL A 320
THR A 323
LEU A 306
VAL A 340
 None
 0.89A 1jgsA-5yjhA:
undetectable		 1jgsA-5yjhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.95A 1rxcB-5yjhA:
undetectable		 1rxcB-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.91A 1rxcE-5yjhA:
undetectable		 1rxcE-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.94A 1rxcI-5yjhA:
undetectable		 1rxcI-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 5 LEU A 105
GLY A 103
HIS A 100
ILE A 126
 None
 0.96A 1xf1A-5yjhA:
undetectable		 1xf1A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 6 HIS A 198
ASN A 201
ILE A  68
THR A 205
 None
None
None
MG  A 728 (-3.6A)
 1.07A 2hkkA-5yjhA:
undetectable		 2hkkA-5yjhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 10 ILE A 492
ILE A 468
SER A 477
PHE A 488
THR A 451
 None
 1.21A 2w9sF-5yjhA:
undetectable		 2w9sF-5yjhA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5yjh PERIOSTIN
(Homo
sapiens) 		3 / 3 LYS A 349
LYS A 344
VAL A 346
 None
 0.83A 3brfA-5yjhA:
undetectable		 3brfA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 THR A 270
VAL A 357
VAL A 352
TYR A 199
ASN A 197
 None
None
None
None
MG  A 728 (-3.6A)
 1.27A 3d4sA-5yjhA:
undetectable		 3d4sA-5yjhA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 VAL A 108
ALA A 110
TYR A  56
VAL A 101
THR A 104
 None
MG  A 722 (-3.0A)
None
None
MG  A 720 (-3.1A)
 0.87A 3dl9A-5yjhA:
undetectable		 3dl9A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.97A 4e1vA-5yjhA:
undetectable		 4e1vA-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.95A 4e1vD-5yjhA:
undetectable		 4e1vD-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.94A 4e1vE-5yjhA:
undetectable		 4e1vE-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.87A 4e1vG-5yjhA:
undetectable		 4e1vG-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 THR A 104
GLY A 109
ILE A 107
PRO A  81
 MG  A 720 (-3.1A)
None
MG  A 720 ( 4.7A)
None
 0.94A 4e1vH-5yjhA:
undetectable		 4e1vH-5yjhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 9 PHE A 534
HIS A 622
PHE A 577
ILE A 584
 None
 1.11A 4jvlA-5yjhA:
undetectable		 4jvlA-5yjhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 8 GLY A 264
THR A 353
LEU A 271
ASN A 355
 None
 1.13A 4m5mA-5yjhA:
undetectable		 4m5mA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 10 LEU A 247
HIS A 359
LEU A 360
ALA A 273
LEU A 271
 MG  A 723 ( 4.7A)
None
None
None
None
 0.94A 4p65A-5yjhA:
undetectable
4p65B-5yjhA:
undetectable
4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable		 4p65A-5yjhA:
undetectable
4p65B-5yjhA:
undetectable
4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 LEU A 271
LEU A 247
HIS A 359
LEU A 360
ALA A 273
 None
MG  A 723 ( 4.7A)
None
None
None
 0.96A 4p65B-5yjhA:
undetectable
4p65D-5yjhA:
undetectable
4p65I-5yjhA:
undetectable
4p65J-5yjhA:
undetectable		 4p65B-5yjhA:
undetectable
4p65D-5yjhA:
undetectable
4p65I-5yjhA:
undetectable
4p65J-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 LEU A 271
LEU A 247
HIS A 359
LEU A 360
ALA A 273
 None
MG  A 723 ( 4.7A)
None
None
None
 0.90A 4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable
4p65K-5yjhA:
undetectable
4p65L-5yjhA:
undetectable		 4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable
4p65K-5yjhA:
undetectable
4p65L-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 ASN A 538
LEU A 503
LEU A 525
LYS A 522
ALA A 519
 MG  A 725 (-3.7A)
None
None
None
None
 1.39A 4rtbA-5yjhA:
undetectable		 4rtbA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 MET A 174
LEU A 175
GLY A 214
ILE A 170
PHE A 135
 None
None
CL  A 711 ( 4.4A)
None
None
 0.98A 4udcA-5yjhA:
undetectable		 4udcA-5yjhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		5 / 12 SER A 612
LEU A 602
GLY A 574
PHE A 577
LEU A 595
 MG  A 727 (-2.8A)
MG  A 727 (-3.8A)
MG  A 727 (-3.5A)
None
None
 1.42A 5jo9A-5yjhA:
undetectable		 5jo9A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 4 SER A 609
THR A 532
ASP A 530
ASP A 613
 None
None
MG  A 721 (-3.5A)
MG  A 727 (-2.9A)
 1.46A 5vimA-5yjhA:
undetectable		 5vimA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5yjh PERIOSTIN
(Homo
sapiens) 		4 / 4 SER A 609
THR A 532
ASP A 530
ASP A 613
 None
None
MG  A 721 (-3.5A)
MG  A 727 (-2.9A)
 1.48A 5vimB-5yjhA:
undetectable		 5vimB-5yjhA:
undetectable