SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yjj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		3 / 3 SER A 433
TYR A 384
HIS A 383
 None
 0.78A 2r2vD-5yjjA:
undetectable		 2r2vD-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 8 VAL A  40
GLU A  65
ALA A  69
PRO A 126
 None
 1.06A 2v41G-5yjjA:
undetectable
2v41H-5yjjA:
undetectable		 2v41G-5yjjA:
undetectable
2v41H-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.86A 3cyxB-5yjjA:
undetectable		 3cyxB-5yjjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 ILE A 132
ALA A 150
ILE A 222
PHE A 218
LEU A 215
 None
 1.07A 3dzuA-5yjjA:
undetectable		 3dzuA-5yjjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 ILE A 506
ALA A 530
SER A 441
LEU A 410
ARG A 413
 None
None
MG  A 802 ( 3.6A)
None
None
 1.19A 3eigA-5yjjA:
undetectable		 3eigA-5yjjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A303_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 4 ASN A 153
SER A 173
SER A 194
ARG A 174
 None
 1.43A 3hlwA-5yjjA:
undetectable		 3hlwA-5yjjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 5 ASN A 153
SER A 173
SER A 194
ARG A 174
 None
 1.45A 3hlwB-5yjjA:
undetectable		 3hlwB-5yjjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 10 SER A 441
LEU A 331
ILE A 537
SER A 446
GLY A 467
 MG  A 802 ( 3.6A)
None
None
None
None
 1.19A 3ik6B-5yjjA:
undetectable
3ik6E-5yjjA:
undetectable		 3ik6B-5yjjA:
18.72
3ik6E-5yjjA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 6 LEU A 410
VAL A 459
VAL A 465
ILE A 431
 None
 1.25A 3k5vB-5yjjA:
undetectable		 3k5vB-5yjjA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.80A 3nu5B-5yjjA:
undetectable		 3nu5B-5yjjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 9 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.81A 3oxvA-5yjjA:
undetectable		 3oxvA-5yjjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 9 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.78A 3oxvC-5yjjA:
undetectable		 3oxvC-5yjjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 337
LEU A 452
ALA A 354
SER A 433
LEU A 355
 None
 1.32A 4m11A-5yjjA:
undetectable		 4m11A-5yjjA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 ILE A 212
ILE A 113
LEU A  59
ILE A  95
ASN A 153
 None
 1.14A 4o1eA-5yjjA:
undetectable		 4o1eA-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 6 GLU A 332
THR A 348
GLN A  23
LEU A 337
 None
 1.25A 4qzuC-5yjjA:
undetectable		 4qzuC-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 8 GLY A 147
GLN A 146
SER A 135
SER A 141
 None
 0.98A 4ws1A-5yjjA:
undetectable		 4ws1A-5yjjA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 ILE A  95
SER A 134
GLY A 133
ALA A 130
THR A  91
 None
 1.27A 4xt8A-5yjjA:
undetectable		 4xt8A-5yjjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		3 / 3 VAL A   7
GLU A 332
GLU A 334
 None
 0.59A 5jsdB-5yjjA:
undetectable
5jsdC-5yjjA:
1.0		 5jsdB-5yjjA:
10.22
5jsdC-5yjjA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		6 / 9 THR A 394
ALA A  45
THR A  44
ALA A  31
ALA A 137
GLY A 392
 None
 1.44A 5l5zK-5yjjA:
undetectable
5l5zL-5yjjA:
undetectable		 5l5zK-5yjjA:
16.83
5l5zL-5yjjA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		6 / 9 THR A 394
ALA A  45
THR A  44
ALA A  31
ALA A 137
GLY A 392
 None
 1.44A 5l5zY-5yjjA:
undetectable
5l5zZ-5yjjA:
undetectable		 5l5zY-5yjjA:
16.83
5l5zZ-5yjjA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 5 HIS A 382
ILE A 431
SER A 446
ALA A 453
 None
 0.97A 5msdA-5yjjA:
undetectable		 5msdA-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.87A 6dh6A-5yjjA:
undetectable		 6dh6A-5yjjA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
epidermidis) 		4 / 7 ALA A 466
THR A 451
ILE A 461
ALA A 463
 None
 0.77A 6ma7A-5yjjA:
undetectable		 6ma7A-5yjjA:
21.59