SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
None
8W6  A 304 (-3.9A)
8W6  A 304 (-3.7A)
 0.76A 1ei6C-5yjpA:
undetectable		 1ei6C-5yjpA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
None
None
8W6  A 304 ( 4.1A)
None
None
 1.44A 2oxtD-5yjpA:
undetectable		 2oxtD-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		3 / 3 LEU A  46
ARG A  49
ILE A  47
 None
 0.60A 2xn5B-5yjpA:
undetectable		 2xn5B-5yjpA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		5 / 12 ILE A  73
SER A  22
GLY A 142
GLY A 140
TYR A  32
 None
 1.27A 2zw9A-5yjpA:
undetectable		 2zw9A-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		3 / 3 GLY A 193
GLY A 151
GLY A 142
 8W6  A 304 ( 4.1A)
None
None
 0.32A 3bogD-5yjpA:
undetectable		 3bogD-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		5 / 10 GLY A  43
GLY A  44
LEU A  53
VAL A  85
ILE A  64
 None
 1.08A 3em4V-5yjpA:
undetectable		 3em4V-5yjpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		4 / 7 MET A  30
LEU A 155
LEU A 200
PHE A  45
 None
 1.21A 3nk2X-5yjpA:
undetectable		 3nk2X-5yjpA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		4 / 7 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
None
8W6  A 304 (-3.9A)
8W6  A 304 (-3.7A)
 0.89A 3t01A-5yjpA:
undetectable		 3t01A-5yjpA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		3 / 3 SER A  26
ALA A 117
VAL A 118
 None
 0.62A 4o2bA-5yjpA:
undetectable		 4o2bA-5yjpA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		5 / 9 PRO A 198
LEU A  33
ILE A 212
VAL A  52
THR A  54
 None
 1.45A 4x3mA-5yjpA:
undetectable		 4x3mA-5yjpA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
8W6  A 304 ( 4.1A)
None
None
 1.30A 5eiwC-5yjpA:
undetectable		 5eiwC-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5yjp HUMAN CHYMASE
(Homo
sapiens) 		5 / 12 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 0.95A 5jo9A-5yjpA:
undetectable		 5jo9A-5yjpA:
undetectable