SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.03A 1o76B-5yk2A:
undetectable		 1o76B-5yk2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.06A 2cppA-5yk2A:
undetectable		 2cppA-5yk2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 268
PHE A 227
ARG A 278
LEU A 431
 None
 1.08A 2eikA-5yk2A:
undetectable
2eikJ-5yk2A:
undetectable		 2eikA-5yk2A:
21.51
2eikJ-5yk2A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 217
PHE A 315
SER A 432
ILE A 428
 None
 1.40A 2v0mD-5yk2A:
undetectable		 2v0mD-5yk2A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.08A 2zuiA-5yk2A:
undetectable		 2zuiA-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.11A 3fwgA-5yk2A:
undetectable		 3fwgA-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 360
PHE A 371
GLN A 367
PRO A 365
 None
 1.47A 3gclA-5yk2A:
undetectable		 3gclA-5yk2A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		3 / 3 MET A 381
CYH A 420
PRO A 365
 None
 1.32A 3h52C-5yk2A:
undetectable		 3h52C-5yk2A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 135
VAL A 143
ALA A 155
LYS A 157
GLU A 210
 None
 0.72A 3hegA-5yk2A:
6.0		 3hegA-5yk2A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 202
GLN A 159
ARG A 168
ASP A 164
 None
 1.04A 3mjrD-5yk2A:
undetectable		 3mjrD-5yk2A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.09A 3wrhE-5yk2A:
undetectable		 3wrhE-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.10A 3wrjE-5yk2A:
undetectable		 3wrjE-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 405
LEU A 343
ILE A 344
THR A 322
 None
 0.95A 4do3B-5yk2A:
undetectable		 4do3B-5yk2A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.11A 4ek1A-5yk2A:
undetectable		 4ek1A-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.08A 4g3rB-5yk2A:
undetectable		 4g3rB-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.08A 4l49A-5yk2A:
undetectable		 4l49A-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 268
GLY A 266
LEU A 431
ILE A 302
PHE A 292
 None
 1.20A 4p6xA-5yk2A:
undetectable		 4p6xA-5yk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 268
GLY A 266
LEU A 431
ILE A 302
PHE A 292
 None
 1.29A 4p6xE-5yk2A:
undetectable		 4p6xE-5yk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 268
GLY A 266
LEU A 431
ILE A 302
PHE A 292
 None
 1.27A 4p6xI-5yk2A:
undetectable		 4p6xI-5yk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 115
PHE A 127
ILE A 158
ILE A 303
ILE A 241
 None
 1.16A 5y2tB-5yk2A:
undetectable		 5y2tB-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		11 / 11 GLU A 196
GLU A 199
ARG A 200
GLY A 285
ASP A 286
ALA A 307
ALA A 309
PRO A 310
ILE A 407
ARG A 410
VAL A 411
 ERY  A 501 (-2.9A)
ERY  A 501 ( 4.0A)
None
ERY  A 501 ( 3.7A)
ERY  A 501 (-4.2A)
ERY  A 501 (-3.8A)
ERY  A 501 (-3.3A)
ERY  A 501 ( 4.7A)
ERY  A 501 (-4.1A)
ERY  A 501 (-4.1A)
None
 0.06A 5yk2A-5yk2A:
57.7		 5yk2A-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 422
GLY A 266
ILE A 428
VAL A 415
ILE A 412
 None
 1.07A 6ectA-5yk2A:
undetectable		 6ectA-5yk2A:
23.59