SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		5 / 11 THR B  60
GLU B  58
GLU B 124
LEU B 180
ILE B 167
 None
 1.24A 1t6zB-5yk7B:
undetectable		 1t6zB-5yk7B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		3 / 3 ARG A 379
ARG A 337
ILE A 301
 None
 0.81A 1uobA-5yk7A:
undetectable		 1uobA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae;
Zygosaccharomyce
s
rouxii) 		5 / 12 LEU A 258
TYR A 261
ILE B 119
ILE B  59
ILE A 400
 None
 1.40A 2efjA-5yk7A:
undetectable		 2efjA-5yk7A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae;
Zygosaccharomyce
s
rouxii) 		5 / 12 ILE B 119
ALA B 169
LEU B 123
PHE B 121
LEU A 327
 None
 1.22A 3ia4D-5yk7B:
undetectable		 3ia4D-5yk7B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		3 / 3 SER A 280
ASP A 220
ASP A 302
 None
 0.80A 3iv6C-5yk7A:
undetectable		 3iv6C-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 171
CYH B 170
TYR B  67
PHE B  66
 None
 1.19A 3po7A-5yk7B:
undetectable		 3po7A-5yk7B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		4 / 5 LEU A 258
PRO A 259
LEU A 262
ILE A 265
 None
 0.92A 4klrA-5yk7A:
undetectable		 4klrA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		4 / 6 LEU A 204
ILE A 203
LEU A 295
TYR A 286
 None
 0.88A 4w5nA-5yk7A:
undetectable		 4w5nA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		4 / 4 TYR A 261
GLY A 401
SER A 402
LEU A 403
 None
 1.45A 5bphC-5yk7A:
undetectable		 5bphC-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		3 / 3 ARG A 415
LYS A 410
GLU A 414
 PO4  A 502 (-3.3A)
None
None
 0.64A 5d0yA-5yk7A:
undetectable		 5d0yA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		3 / 3 ILE A 397
PRO A 398
ILE A 400
 None
 0.41A 5hw8F-5yk7A:
undetectable		 5hw8F-5yk7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1
(Zygosaccharomyce
s
rouxii) 		4 / 8 PHE A 222
PHE A 338
PRO A 277
ILE A 230
 None
 1.06A 5vkqB-5yk7A:
undetectable
5vkqC-5yk7A:
undetectable		 5vkqB-5yk7A:
undetectable
5vkqC-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 224
ASP B 223
LYS B 227
 None
 0.86A 6awtD-5yk7B:
2.5		 6awtD-5yk7B:
undetectable