SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ykb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		3 / 3 PHE A 424
LEU A  78
SER A  18
 None
 0.78A 1e7aA-5ykbA:
undetectable		 1e7aA-5ykbA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 ARG A  62
ASP A 162
TYR A 135
TYR A 169
ASP A 110
 None
 1.33A 1e7wA-5ykbA:
undetectable		 1e7wA-5ykbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 483
SER A 498
PHE A 500
THR A 370
LEU A 375
 None
 1.27A 1fo4A-5ykbA:
undetectable		 1fo4A-5ykbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 10 GLY A 245
ALA A 195
LEU A 199
HIS A 192
PHE A 235
 None
 1.24A 1jglH-5ykbA:
undetectable
1jglL-5ykbA:
undetectable		 1jglH-5ykbA:
15.36
1jglL-5ykbA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 7 TYR A 131
TRP A 113
TYR A  71
GLY A  73
 None
 1.02A 1mxgA-5ykbA:
24.1		 1mxgA-5ykbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 7 LEU A 395
PHE A 415
VAL A  19
SER A  18
 None
 1.00A 1wrlA-5ykbA:
undetectable
1wrlB-5ykbA:
undetectable		 1wrlA-5ykbA:
9.84
1wrlB-5ykbA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 11 VAL A 440
ILE A 387
LEU A 451
LEU A  43
LEU A  46
 None
 1.19A 2a15A-5ykbA:
undetectable		 2a15A-5ykbA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 10 ASN A 317
GLU A 386
LEU A  46
LEU A  43
TYR A  42
 None
 1.33A 2ha6A-5ykbA:
undetectable		 2ha6A-5ykbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		3 / 3 ASN A 399
ARG A 402
ASP A  67
 None
 0.93A 2qe6A-5ykbA:
undetectable		 2qe6A-5ykbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		3 / 3 ASN A 399
ARG A 402
ASP A  67
 None
 0.90A 2qe6B-5ykbA:
undetectable		 2qe6B-5ykbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 PRO A 538
GLN A 488
THR A 493
ILE A 475
ASP A 510
 None
 1.06A 2v95A-5ykbA:
undetectable		 2v95A-5ykbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 352
ARG A 316
PRO A 356
 None
 0.86A 2wljA-5ykbA:
undetectable		 2wljA-5ykbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 GLN A 406
PHE A 425
GLY A 384
ARG A 353
LEU A  17
 None
 1.43A 3aodC-5ykbA:
undetectable		 3aodC-5ykbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 11 ALA A 374
LEU A 373
ILE A 313
PRO A 379
GLY A 377
 None
 1.38A 3bpxA-5ykbA:
undetectable
3bpxB-5ykbA:
undetectable		 3bpxA-5ykbA:
14.13
3bpxB-5ykbA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 450
LEU A 451
LEU A 444
GLN A 441
MET A 405
 None
 1.20A 3d90B-5ykbA:
undetectable		 3d90B-5ykbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A 444
LEU A 451
MET A 405
PHE A  22
 None
 1.33A 3g1uA-5ykbA:
undetectable		 3g1uA-5ykbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A 444
LEU A 451
MET A 405
PHE A  22
 None
 1.33A 3g1uB-5ykbA:
2.1		 3g1uB-5ykbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A 444
LEU A 451
MET A 405
PHE A  22
 None
 1.41A 3g1uC-5ykbA:
undetectable		 3g1uC-5ykbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 8 ASN A 369
THR A 454
LEU A 451
GLN A 443
 None
 0.93A 3kp6A-5ykbA:
undetectable		 3kp6A-5ykbA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 483
PHE A 500
LEU A 283
GLY A 300
LEU A 302
 None
 1.25A 3tbgA-5ykbA:
undetectable		 3tbgA-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 483
PHE A 500
LEU A 283
GLY A 300
LEU A 302
 None
 1.27A 3tbgC-5ykbA:
undetectable		 3tbgC-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 483
SER A 498
PHE A 500
THR A 370
LEU A 375
 None
 1.27A 3uncA-5ykbA:
undetectable		 3uncA-5ykbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 483
SER A 498
PHE A 500
THR A 370
LEU A 375
 None
 1.28A 3uncB-5ykbA:
undetectable		 3uncB-5ykbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 9 ALA A 210
LEU A 191
LEU A 214
ASN A 224
ILE A 231
 None
 1.16A 3wdmC-5ykbA:
undetectable		 3wdmC-5ykbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 7 LEU A 393
ARG A 316
ARG A 353
PRO A 426
 None
 0.99A 4klrA-5ykbA:
undetectable		 4klrA-5ykbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 197
GLY A  79
LEU A  78
VAL A  19
VAL A  68
 None
 1.07A 4wnwB-5ykbA:
undetectable		 4wnwB-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 PHE A  14
ILE A 305
PHE A 275
LEU A 249
LEU A 247
 None
 1.28A 4xumA-5ykbA:
undetectable		 4xumA-5ykbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 6 GLU A 386
GLY A 100
ASP A 101
ARG A 207
 None
 0.90A 5cdpA-5ykbA:
undetectable
5cdpB-5ykbA:
undetectable		 5cdpA-5ykbA:
20.88
5cdpB-5ykbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 5 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 1.04A 5gtrA-5ykbA:
undetectable		 5gtrA-5ykbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		4 / 5 SER A 109
SER A 108
SER A 176
SER A  59
 None
 1.50A 5hswA-5ykbA:
undetectable		 5hswA-5ykbA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 474
ARG A 282
ARG A 487
PRO A 376
LEU A 375
 None
 1.34A 5nd2B-5ykbA:
undetectable		 5nd2B-5ykbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 367
TYR A 547
MET A 541
ILE A 482
GLU A 290
 None
 1.45A 5w8aA-5ykbA:
undetectable		 5w8aA-5ykbA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 205
PRO A 244
GLY A 245
ASP A 101
ASP A 204
 None
 1.32A 5yn6A-5ykbA:
undetectable		 5yn6A-5ykbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 205
PRO A 244
GLY A 245
ASP A 101
ASP A 204
 None
 1.34A 5yniA-5ykbA:
undetectable		 5yniA-5ykbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  53
GLY A 100
SER A  59
ASP A  63
VAL A 103
 None
 1.25A 6bxlA-5ykbA:
undetectable		 6bxlA-5ykbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ykb TREHALOSE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 339
LEU A 357
HIS A 318
LEU A 323
TYR A 335
 None
 1.18A 6djzC-5ykbA:
undetectable		 6djzC-5ykbA:
17.89