SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ykh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 8 PHE A  78
ILE A  58
LEU A  43
VAL A  54
 None
 0.71A 1fslB-5ykhA:
undetectable		 1fslB-5ykhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 8 HIS A 133
LEU A  99
ALA A 102
LEU A 103
 None
 1.01A 1hwiB-5ykhA:
undetectable		 1hwiB-5ykhA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 8 HIS A 133
LEU A  99
ALA A 102
LEU A 103
 None
 0.98A 1hwiC-5ykhA:
undetectable		 1hwiC-5ykhA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 4 LEU A 173
VAL A 183
CYH A 186
ALA A 190
 None
 1.18A 1mz9E-5ykhA:
undetectable		 1mz9E-5ykhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		5 / 12 ALA A  62
LEU A  90
GLN A  40
LEU A  43
VAL A  54
 None
 1.11A 1u72A-5ykhA:
undetectable		 1u72A-5ykhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 9 ILE A 162
ALA A 179
VAL A 182
CYH A 186
 None
 0.95A 2vufB-5ykhA:
undetectable		 2vufB-5ykhA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 9 ILE A 277
ALA A 294
VAL A 297
CYH A 301
 None
 0.93A 2vufB-5ykhA:
undetectable		 2vufB-5ykhA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		3 / 3 LEU A 245
HIS A 246
MET A 242
 None
 0.80A 3thrD-5ykhA:
undetectable		 3thrD-5ykhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		5 / 12 VAL A  54
GLY A  71
ILE A  58
SER A  36
LEU A  43
 None
 1.00A 4iv0A-5ykhA:
undetectable		 4iv0A-5ykhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		5 / 12 VAL A  54
GLY A  71
ILE A  58
SER A  36
LEU A  43
 None
 0.97A 4mwzB-5ykhA:
undetectable		 4mwzB-5ykhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		4 / 8 ILE A  39
PHE A  29
GLN A  31
GLU A  28
 None
 0.88A 5dqyA-5ykhA:
undetectable		 5dqyA-5ykhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5ykh PUMILIO HOMOLOG 1
(Homo
sapiens) 		3 / 3 GLN A 227
TYR A 224
ASN A 223
 None
 0.68A 6dwdC-5ykhA:
undetectable		 6dwdC-5ykhA:
undetectable