SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.86A 2dyrN-5yksA:
undetectable
2dyrW-5yksA:
undetectable		 2dyrN-5yksA:
19.85
2dyrW-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.85A 2eijN-5yksA:
undetectable
2eijW-5yksA:
undetectable		 2eijN-5yksA:
19.85
2eijW-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		3 / 3 LYS A  87
GLY A  -2
PRO A  -1
 None
 0.95A 2hreB-5yksA:
undetectable		 2hreB-5yksA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		3 / 3 GLN A 122
LYS A 155
VAL A 145
 None
 0.66A 2jfaB-5yksA:
undetectable		 2jfaB-5yksA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 SER A 128
CYH A 130
GLN A 122
ILE A  75
 None
 1.10A 2xz5A-5yksA:
undetectable
2xz5B-5yksA:
undetectable		 2xz5A-5yksA:
19.85
2xz5B-5yksA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 SER A 128
CYH A 130
GLN A 122
ILE A  75
 None
 1.17A 2xz5B-5yksA:
undetectable
2xz5E-5yksA:
undetectable		 2xz5B-5yksA:
19.85
2xz5E-5yksA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.86A 3ablA-5yksA:
1.8
3ablJ-5yksA:
undetectable		 3ablA-5yksA:
19.85
3ablJ-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.85A 3ag3N-5yksA:
2.0
3ag3W-5yksA:
undetectable		 3ag3N-5yksA:
19.85
3ag3W-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		5 / 12 LEU A 156
ILE A 204
LEU A 245
LEU A 201
ALA A 121
 None
 1.19A 4m11A-5yksA:
undetectable		 4m11A-5yksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.81A 5b1bA-5yksA:
1.6
5b1bJ-5yksA:
undetectable		 5b1bA-5yksA:
19.85
5b1bJ-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.84A 5iy5A-5yksA:
undetectable
5iy5J-5yksA:
undetectable		 5iy5A-5yksA:
19.85
5iy5J-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 6 HIS A 137
MET A  67
ASN A  74
VAL A  76
 None
 1.48A 5xdhA-5yksA:
undetectable
5xdhC-5yksA:
undetectable		 5xdhA-5yksA:
12.54
5xdhC-5yksA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.74A 5xdqA-5yksA:
undetectable
5xdqJ-5yksA:
undetectable		 5xdqA-5yksA:
19.85
5xdqJ-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.82A 5xdxN-5yksA:
1.8
5xdxW-5yksA:
undetectable		 5xdxN-5yksA:
19.85
5xdxW-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		6 / 12 ALA A  43
LEU A  90
GLY A  98
ASP A 102
THR A 157
ASP A 158
 None
 0.93A 5yu9C-5yksA:
19.3		 5yu9C-5yksA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.81A 5zcoA-5yksA:
1.8
5zcoJ-5yksA:
undetectable		 5zcoA-5yksA:
19.85
5zcoJ-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 8 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.83A 5zcqN-5yksA:
undetectable
5zcqW-5yksA:
undetectable		 5zcqN-5yksA:
19.85
5zcqW-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		5 / 12 LEU A 201
LEU A 140
ILE A  75
ALA A 126
HIS A 131
 None
 1.24A 6n91B-5yksA:
undetectable		 6n91B-5yksA:
16.09