SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		5 / 9 CYH B 135
LEU B  80
ALA B  75
LEU B  27
LEU B  71
 None
 1.48A 1hwiA-5yllB:
undetectable		 1hwiA-5yllB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 ASP B 290
ASP B 274
LYS B 296
 None
 0.72A 1lqtB-5yllB:
undetectable		 1lqtB-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 ASP B 290
ASP B 274
LYS B 296
 None
 0.70A 1lquB-5yllB:
undetectable		 1lquB-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 6 ASP B 188
LEU B 168
GLY B 167
ARG B 162
 None
 0.81A 1mt1G-5yllB:
0.0
1mt1J-5yllB:
undetectable		 1mt1G-5yllB:
23.38
1mt1J-5yllB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 6 ARG B 162
ASP B 188
LEU B 168
GLY B 167
 None
 0.85A 1n13H-5yllB:
undetectable
1n13K-5yllB:
0.0		 1n13H-5yllB:
17.59
1n13K-5yllB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 7 ASP B 188
LEU B 168
GLY B 167
ARG B 162
 None
 0.83A 1n13G-5yllB:
0.0
1n13J-5yllB:
undetectable		 1n13G-5yllB:
23.38
1n13J-5yllB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 TRP B 112
PHE B 116
TRP B 154
 None
 1.45A 1r15C-5yllB:
2.5		 1r15C-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 TRP B 112
PHE B 116
TRP B 154
 None
 1.45A 1r15F-5yllB:
2.5		 1r15F-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 TRP B 112
PHE B 116
TRP B 154
 None
 1.45A 1r15G-5yllB:
2.5		 1r15G-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 TRP B 112
PHE B 116
TRP B 154
 None
 1.44A 1r15H-5yllB:
2.5		 1r15H-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		5 / 10 ALA B  44
ALA B  42
VAL B  82
LEU B  71
GLN B 123
 None
 1.33A 1rlbE-5yllB:
undetectable		 1rlbE-5yllB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 ALA B 210
VAL B 212
TRP B 184
 None
 0.84A 1tkqA-5yllB:
undetectable		 1tkqA-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 7 ARG B 162
ASP B 188
LEU B 168
GLY B 167
 None
 0.84A 2qqcD-5yllB:
undetectable
2qqcE-5yllB:
undetectable		 2qqcD-5yllB:
21.88
2qqcE-5yllB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 8 ARG B 162
ASP B 188
LEU B 168
GLY B 167
 None
 0.80A 2qqdB-5yllB:
undetectable
2qqdC-5yllB:
undetectable		 2qqdB-5yllB:
17.59
2qqdC-5yllB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		3 / 3 TYR B 195
GLU B 143
ASN B  89
 BMA  B 401 (-4.5A)
BMA  B 401 (-2.6A)
BMA  B 402 (-3.0A)
 0.96A 2y7hC-5yllB:
undetectable		 2y7hC-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 7 TYR B 122
TYR B 126
TRP B 273
TRP B  11
 None
None
BMA  B 401 (-3.5A)
BMA  B 402 (-4.1A)
 1.45A 3cotA-5yllB:
9.6		 3cotA-5yllB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		5 / 12 ASP B 274
ILE B 302
TYR B 254
PRO B 227
PHE B   7
 None
 1.27A 4drhD-5yllB:
undetectable		 4drhD-5yllB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		5 / 12 ARG B 309
ILE B  83
GLY B 268
GLY B   6
LEU B 272
 None
 1.10A 4e1gB-5yllB:
undetectable		 4e1gB-5yllB:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 7 ARG B 309
ILE B 302
PHE B 258
LEU B 272
 None
 0.98A 4mmcA-5yllB:
undetectable		 4mmcA-5yllB:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 5 ILE B 120
ASP B 152
GLU B 160
VAL B 140
 None
 1.20A 4nkxC-5yllB:
undetectable		 4nkxC-5yllB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 5 ILE B 120
ASP B 152
GLU B 160
VAL B 140
 None
 1.25A 4nkxD-5yllB:
undetectable		 4nkxD-5yllB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 6 PHE B   7
LEU B  27
TRP B 275
GLY B  10
 None
 1.08A 5o4yA-5yllB:
undetectable		 5o4yA-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 6 PHE B   7
LEU B  27
TRP B 275
GLY B  10
 None
 1.00A 5o4yF-5yllB:
undetectable		 5o4yF-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5yll BETA-1,4-MANNANASE
(Amphibacillus
xylanus) 		4 / 8 ILE B 120
TRP B 154
VAL B 140
ASP B 164
 None
 0.84A 5vlmF-5yllB:
undetectable		 5vlmF-5yllB:
undetectable