SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		4 / 8 VAL A 858
GLY A 857
TYR A 826
GLU A 850
 None
 0.90A 1jlfA-5ylyA:
undetectable
1jlfB-5ylyA:
undetectable		 1jlfA-5ylyA:
8.79
1jlfB-5ylyA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		5 / 12 GLY A 625
VAL A 703
LEU A 609
ASP A 629
LEU A 633
 None
 1.24A 3cjtK-5ylyA:
undetectable		 3cjtK-5ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		5 / 12 SER A 616
ILE A 615
THR A 662
ALA A 775
THR A 773
 None
None
FAD  A1001 (-4.6A)
None
None
 1.18A 3ua1A-5ylyA:
undetectable		 3ua1A-5ylyA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		4 / 8 ILE A 765
ILE A 755
SER A 731
GLY A 722
 None
 0.81A 4acbC-5ylyA:
3.3		 4acbC-5ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		5 / 12 ILE A 679
VAL A 647
ILE A 697
GLU A 655
ARG A 659
 None
None
None
None
FAD  A1001 (-3.8A)
 1.10A 4i41A-5ylyA:
undetectable		 4i41A-5ylyA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		4 / 6 ASP A 618
THR A 746
THR A 664
VAL A 676
 None
FAD  A1001 (-2.8A)
None
None
 0.91A 4yoaA-5ylyA:
undetectable		 4yoaA-5ylyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		5 / 12 ASN A 726
HIS A 727
GLU A 862
SER A 832
GLY A 857
 None
 1.37A 5fqdE-5ylyA:
undetectable
5fqdF-5ylyA:
0.6		 5fqdE-5ylyA:
11.78
5fqdF-5ylyA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		3 / 3 PRO A 721
LEU A 756
SER A 760
 None
 0.80A 5fsaB-5ylyA:
undetectable		 5fsaB-5ylyA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5yly NITRATE REDUCTASE
(Ulva
prolifera) 		4 / 8 THR A 743
GLY A 744
CYH A 835
GLY A 836
 FAD  A1001 (-3.4A)
None
FAD  A1001 ( 4.5A)
None
 0.45A 5vw5A-5ylyA:
19.8		 5vw5A-5ylyA:
undetectable