SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ynl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 5 GLY A 268
LEU A 247
THR A 264
VAL A 134
 None
 0.97A 1ekjF-5ynlA:
undetectable
1ekjG-5ynlA:
undetectable		 1ekjF-5ynlA:
undetectable
1ekjG-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 LEU A 108
LEU A  38
SER A  41
VAL A 106
LEU A 314
 None
 1.20A 1ie9A-5ynlA:
undetectable		 1ie9A-5ynlA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		3 / 3 SER A 241
GLU A 288
ASP A 194
 None
 0.87A 2avdB-5ynlA:
2.8		 2avdB-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 6 LEU A 201
TYR A 187
ILE A 193
ILE A 140
 None
 0.81A 2q8hA-5ynlA:
undetectable		 2q8hA-5ynlA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 10 HIS A 137
ILE A 193
LEU A 190
GLY A 189
ALA A 246
 None
 1.26A 2xf3A-5ynlA:
undetectable		 2xf3A-5ynlA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 10 LEU A 280
LEU A 227
LEU A 240
ILE A 238
VAL A 222
 None
 1.15A 3r9cA-5ynlA:
undetectable		 3r9cA-5ynlA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 ILE A 271
ALA A 313
ILE A 286
PHE A 242
LEU A 247
 None
 1.09A 4cd2A-5ynlA:
undetectable		 4cd2A-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 GLY A 220
GLY A 218
ILE A 271
ALA A 274
MET A 225
 None
 1.15A 4kicA-5ynlA:
undetectable		 4kicA-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 LEU A 131
GLY A 189
LEU A 190
ALA A 226
VAL A 156
 None
 0.90A 4wnwB-5ynlA:
undetectable		 4wnwB-5ynlA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 8 GLU A 267
GLY A 262
GLY A 261
VAL A 214
 None
 0.78A 5f8yA-5ynlA:
undetectable		 5f8yA-5ynlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 8 GLU A 267
GLY A 262
GLY A 261
VAL A 214
 None
 0.78A 5f8yB-5ynlA:
undetectable		 5f8yB-5ynlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 HIS A  32
GLY A  34
LEU A  38
GLY A 306
THR A 302
 None
 1.05A 5hg0A-5ynlA:
undetectable		 5hg0A-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		5 / 12 HIS A  32
GLY A  34
LEU A  38
GLY A 306
THR A 302
 None
 1.07A 5hg0B-5ynlA:
undetectable		 5hg0B-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 4 ASP A 304
ILE A 289
PRO A  35
LEU A  38
 None
 1.35A 6mkeB-5ynlA:
undetectable		 6mkeB-5ynlA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5ynl ARGINASE
(Glaciozyma
antarctica) 		4 / 4 ASP A 304
ILE A 289
PRO A  35
LEU A  38
 None
 1.42A 6mkeA-5ynlA:
undetectable		 6mkeA-5ynlA:
26.44