SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 8 HIS A  55
GLY A  59
THR A 210
ASP A  85
 None
 0.73A 1aegA-5yo8A:
undetectable		 1aegA-5yo8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1fm6D-5yo8A:
undetectable		 1fm6D-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.47A 1fm6X-5yo8A:
undetectable		 1fm6X-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 6 TRP A 303
LEU A 290
LEU A 293
PRO A 294
 None
 1.16A 1hz4A-5yo8A:
3.1		 1hz4A-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 PHE A 298
ILE A  14
LEU A  10
PRO A   7
THR A 215
 None
 1.11A 1jolB-5yo8A:
undetectable		 1jolB-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 6 GLU A 128
LEU A  41
ASP A 131
LEU A 135
 None
 0.97A 1mt1B-5yo8A:
undetectable
1mt1C-5yo8A:
undetectable		 1mt1B-5yo8A:
22.58
1mt1C-5yo8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 211
GLY A  63
TYR A  62
ILE A 302
THR A 292
 None
 1.06A 1p91B-5yo8A:
undetectable		 1p91B-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 8 TYR A  80
PHE A  76
ALA A 111
LEU A 160
 None
 1.09A 1x8vA-5yo8A:
undetectable		 1x8vA-5yo8A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1zgyA-5yo8A:
undetectable		 1zgyA-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 ILE A 307
VAL A 241
GLU A 287
LEU A 290
ARG A 300
 None
 1.32A 2bxfB-5yo8A:
2.4		 2bxfB-5yo8A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 10 GLY A  58
PHE A  54
GLY A 305
HIS A 245
ILE A 306
 None
 1.37A 2y7wB-5yo8A:
undetectable		 2y7wB-5yo8A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 6 LEU A 311
ASP A 249
LEU A 246
HIS A 245
 None
 1.10A 3bj8C-5yo8A:
undetectable
3bj8D-5yo8A:
undetectable		 3bj8C-5yo8A:
16.98
3bj8D-5yo8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 8 ILE A  61
LEU A  19
THR A 218
VAL A  22
GLY A  58
 None
 1.50A 3dcjB-5yo8A:
undetectable		 3dcjB-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		3 / 3 ASP A  85
ARG A  51
LYS A  52
 None
 1.09A 3wipG-5yo8A:
undetectable		 3wipG-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 LEU A  64
GLY A  58
GLY A  60
VAL A  22
PHE A  54
 None
 1.02A 4a6eA-5yo8A:
undetectable		 4a6eA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		3 / 3 GLN A 170
ASP A  85
GLN A  81
 None
 0.91A 4aztA-5yo8A:
undetectable		 4aztA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  63
GLY A  59
GLY A  58
ASP A  68
VAL A   3
 None
 1.09A 4b17A-5yo8A:
undetectable		 4b17A-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 8 ASP A 257
ASP A 313
ASP A 249
GLU A 256
 None
 1.04A 4gkiE-5yo8A:
undetectable
4gkiG-5yo8A:
undetectable		 4gkiE-5yo8A:
18.01
4gkiG-5yo8A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 11 CYH A  84
ILE A  82
LEU A 109
ALA A 112
LEU A 135
 None
 1.05A 4p65E-5yo8A:
undetectable
4p65F-5yo8A:
undetectable
4p65J-5yo8A:
undetectable
4p65L-5yo8A:
undetectable		 4p65E-5yo8A:
undetectable
4p65F-5yo8A:
undetectable
4p65J-5yo8A:
undetectable
4p65L-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 135
CYH A  84
ILE A  82
LEU A 109
ALA A 112
 None
 0.86A 4p65B-5yo8A:
undetectable
4p65D-5yo8A:
undetectable
4p65I-5yo8A:
undetectable
4p65J-5yo8A:
undetectable		 4p65B-5yo8A:
undetectable
4p65D-5yo8A:
undetectable
4p65I-5yo8A:
undetectable
4p65J-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 135
CYH A  84
ILE A  82
LEU A 109
ALA A 112
 None
 0.85A 4p65F-5yo8A:
undetectable
4p65H-5yo8A:
undetectable
4p65K-5yo8A:
undetectable
4p65L-5yo8A:
undetectable		 4p65F-5yo8A:
undetectable
4p65H-5yo8A:
undetectable
4p65K-5yo8A:
undetectable
4p65L-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.43A 4xldA-5yo8A:
undetectable		 4xldA-5yo8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 7 CYH A  84
ILE A  82
LEU A 109
ALA A 112
 None
 0.91A 5hrqE-5yo8A:
undetectable
5hrqF-5yo8A:
undetectable
5hrqJ-5yo8A:
undetectable		 5hrqE-5yo8A:
undetectable
5hrqF-5yo8A:
undetectable
5hrqJ-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		3 / 3 HIS A 191
GLU A 190
TRP A 187
 None
 1.05A 5odiD-5yo8A:
undetectable		 5odiD-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		3 / 3 HIS A 191
GLU A 190
TRP A 187
 None
 0.92A 5odqD-5yo8A:
undetectable		 5odqD-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		3 / 3 HIS A 191
GLU A 190
TRP A 187
 None
 0.99A 5odrD-5yo8A:
undetectable		 5odrD-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 LEU A  19
GLY A  59
TYR A 219
ILE A  74
HIS A 299
 None
 1.11A 5y2tA-5yo8A:
undetectable		 5y2tA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		4 / 5 HIS A 301
GLU A 287
LEU A 248
VAL A 244
 None
 1.10A 6bc9A-5yo8A:
undetectable		 6bc9A-5yo8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 ILE A  61
GLY A  60
ILE A  74
ASP A  17
ILE A  14
 None
 1.01A 6emuB-5yo8A:
undetectable		 6emuB-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE
(Bacillus
alcalophilus) 		5 / 12 ILE A  61
GLY A  60
ILE A  74
ASP A  17
ILE A  14
 None
 1.00A 6emuC-5yo8A:
undetectable		 6emuC-5yo8A:
undetectable