SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 GLU A 217
ALA A 229
SER A 293
 None
 0.70A 1errB-5yowA:
undetectable		 1errB-5yowA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1p7lC-5yowA:
undetectable		 1p7lC-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1p7lD-5yowA:
undetectable		 1p7lD-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9A-5yowA:
undetectable		 1rg9A-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9B-5yowA:
undetectable		 1rg9B-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9C-5yowA:
undetectable		 1rg9C-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9D-5yowA:
undetectable		 1rg9D-5yowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		5 / 12 PHE A  45
VAL A 198
ILE A 172
VAL A  35
LEU A  43
 None
 1.21A 2ft9A-5yowA:
undetectable		 2ft9A-5yowA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 4 VAL A 302
ARG A 303
HIS A 400
PHE A 304
 None
 1.49A 3apwA-5yowA:
undetectable		 3apwA-5yowA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.94A 4k8cA-5yowA:
undetectable		 4k8cA-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.93A 4kahA-5yowA:
undetectable		 4kahA-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.93A 4kahB-5yowA:
undetectable		 4kahB-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.94A 4kanA-5yowA:
undetectable		 4kanA-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.94A 4kanB-5yowA:
undetectable		 4kanB-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.95A 4kbeA-5yowA:
undetectable		 4kbeA-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.92A 4kbeB-5yowA:
undetectable		 4kbeB-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.95A 4lbgA-5yowA:
undetectable		 4lbgA-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		3 / 3 SER A 317
TYR A 315
PRO A  37
 None
 0.93A 4lbgB-5yowA:
undetectable		 4lbgB-5yowA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 6 PHE A 328
LYS A  59
TYR A 202
ALA A 170
 None
FUC  A 504 (-2.9A)
None
None
 1.31A 4yshB-5yowA:
undetectable		 4yshB-5yowA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		5 / 12 GLY A 418
PHE A 328
ILE A 172
GLY A 326
HIS A 378
 None
 1.23A 4zdyA-5yowA:
undetectable		 4zdyA-5yowA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 8 PHE A 145
SER A  84
TRP A 146
TRP A 111
 None
 1.43A 5amiB-5yowA:
undetectable		 5amiB-5yowA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		5 / 12 GLY A 418
PHE A 328
ILE A 172
GLY A 326
HIS A 378
 None
 1.24A 5eslA-5yowA:
undetectable		 5eslA-5yowA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 4 LEU A 228
ARG A 303
ILE A 299
PHE A 304
 None
 1.18A 5kirB-5yowA:
undetectable		 5kirB-5yowA:
19.62