SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 ASP A 499
GLY A 500
THR A 502
PRO A 503
 None
 0.77A 1n4fA-5yp3A:
undetectable		 1n4fA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 8 TYR A 480
GLN A 553
SER A 507
TYR A 492
 None
 1.32A 1nx9A-5yp3A:
9.3		 1nx9A-5yp3A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 9 VAL A 669
LEU A 700
LEU A 704
ARG A 707
ALA A 624
 None
 1.40A 1pbfA-5yp3A:
undetectable		 1pbfA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 SER A 111
GLY A 112
ARG A  61
 None
 0.50A 1t9wA-5yp3A:
undetectable		 1t9wA-5yp3A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.75A 1x70A-5yp3A:
34.6		 1x70A-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TYR A 527
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.42A 1x70A-5yp3A:
34.6		 1x70A-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.78A 1x70B-5yp3A:
34.5		 1x70B-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.49A 1x70B-5yp3A:
34.5		 1x70B-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 5 TRP A 337
PRO A 339
GLY A 574
GLY A 570
 None
 0.89A 1zlqA-5yp3A:
undetectable		 1zlqA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 TRP A 612
THR A 735
TYR A 732
 None
 1.18A 2a3aA-5yp3A:
undetectable		 2a3aA-5yp3A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 TRP A 612
THR A 735
TYR A 732
 None
 1.22A 2a3aB-5yp3A:
undetectable		 2a3aB-5yp3A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 11 VAL A  53
THR A  54
ALA A 436
ALA A 433
ASP A 391
 None
 1.20A 2admB-5yp3A:
undetectable		 2admB-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 LEU A 416
LEU A 377
SER A 355
ALA A 389
ALA A 439
 None
 1.10A 2br4F-5yp3A:
undetectable		 2br4F-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TRP A 612
SER A 613
VAL A 639
TYR A 645
TYR A 649
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
None
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
None
ILE  A 801 (-4.5A)
 0.75A 2rguA-5yp3A:
34.5		 2rguA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		8 / 12 GLU A 208
GLU A 209
TYR A 527
TRP A 612
SER A 613
VAL A 639
TYR A 645
TYR A 649
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
 0.82A 2rguA-5yp3A:
34.5		 2rguA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.19A 2rguA-5yp3A:
34.5		 2rguA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 11 GLU A 208
GLU A 209
TRP A 612
SER A 613
VAL A 639
TYR A 645
TYR A 649
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
None
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
None
ILE  A 801 (-4.5A)
 0.72A 2rguB-5yp3A:
34.6		 2rguB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		8 / 11 GLU A 208
GLU A 209
TYR A 527
TRP A 612
SER A 613
VAL A 639
TYR A 645
TYR A 649
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
 0.82A 2rguB-5yp3A:
34.6		 2rguB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 11 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.23A 2rguB-5yp3A:
34.6		 2rguB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 8 TYR A 732
LEU A 729
LEU A  27
ALA A  29
 None
 0.99A 2wekA-5yp3A:
2.1		 2wekA-5yp3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 SER A 334
SER A 356
TRP A 337
ASP A 343
 None
 1.27A 3bc9A-5yp3A:
undetectable		 3bc9A-5yp3A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.82A 3bjmA-5yp3A:
34.5		 3bjmA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.44A 3bjmA-5yp3A:
34.5		 3bjmA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.10A 3bjmA-5yp3A:
34.5		 3bjmA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.08A 3bjmA-5yp3A:
34.5		 3bjmA-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.83A 3bjmB-5yp3A:
34.2		 3bjmB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.43A 3bjmB-5yp3A:
34.2		 3bjmB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.13A 3bjmB-5yp3A:
34.2		 3bjmB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 GLY A 528
GLU A 585
GLY A 565
ASN A 614
 None
 0.85A 3e9rA-5yp3A:
undetectable		 3e9rA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 GLY A 529
GLU A 585
GLY A 565
ASN A 614
 None
 1.08A 3e9rA-5yp3A:
undetectable		 3e9rA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 GLY A 528
GLU A 585
GLY A 565
ASN A 614
 None
 0.88A 3e9rC-5yp3A:
undetectable		 3e9rC-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 GLY A 529
GLU A 585
GLY A 565
ASN A 614
 None
 1.03A 3e9rC-5yp3A:
undetectable		 3e9rC-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 527
ALA A 637
GLY A 616
ASN A 696
VAL A 692
 PRO  A 802 (-4.7A)
None
None
None
None
 1.17A 3f8wA-5yp3A:
undetectable		 3f8wA-5yp3A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 527
ALA A 637
GLY A 616
ASN A 696
VAL A 692
 PRO  A 802 (-4.7A)
None
None
None
None
 1.16A 3f8wC-5yp3A:
undetectable		 3f8wC-5yp3A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.94A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
 0.98A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.59A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
ILE  A 801 (-4.5A)
 0.74A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.32A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 653
VAL A 639
ASN A 691
VAL A 692
 ILE  A 801 (-3.4A)
None
None
ILE  A 801 (-3.1A)
None
 1.50A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		6 / 12 SER A 613
TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.21A 3g0bA-5yp3A:
37.3		 3g0bA-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.92A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
 0.96A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.57A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
ILE  A 801 (-4.5A)
 0.73A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
SER A 613
VAL A 639
TYR A 645
VAL A 692
 ILE  A 801 (-3.4A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
None
 1.33A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.31A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 653
VAL A 639
ASN A 691
VAL A 692
 ILE  A 801 (-3.4A)
None
None
ILE  A 801 (-3.1A)
None
 1.47A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 SER A 613
TYR A 617
TYR A 645
ASN A 691
VAL A 692
 PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
 1.25A 3g0bB-5yp3A:
34.6		 3g0bB-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
 1.00A 3g0bC-5yp3A:
34.8		 3g0bC-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		8 / 12 ARG A 106
GLU A 208
GLU A 209
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.92A 3g0bC-5yp3A:
34.8		 3g0bC-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		8 / 12 GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
ILE  A 801 (-4.5A)
 0.62A 3g0bC-5yp3A:
34.8		 3g0bC-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		8 / 12 GLU A 208
GLU A 209
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.40A 3g0bC-5yp3A:
34.8		 3g0bC-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.32A 3g0bC-5yp3A:
34.8		 3g0bC-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.94A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
 0.98A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.60A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
ILE  A 801 (-4.5A)
 0.75A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
SER A 613
VAL A 639
TYR A 645
VAL A 692
 ILE  A 801 (-3.4A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
None
 1.33A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.29A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 653
VAL A 639
ASN A 691
VAL A 692
 ILE  A 801 (-3.4A)
None
None
ILE  A 801 (-3.1A)
None
 1.49A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		6 / 12 SER A 613
TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.24A 3g0bD-5yp3A:
34.7		 3g0bD-5yp3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 5 GLN A 426
THR A 425
GLU A 456
THR A 467
 None
 1.48A 3glqA-5yp3A:
4.5		 3glqA-5yp3A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 MET A 621
LEU A 622
GLY A 615
GLY A 616
PRO A 638
 None
 1.13A 3i5uA-5yp3A:
undetectable		 3i5uA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 MET A 621
LEU A 622
GLY A 615
GLY A 616
PRO A 638
 None
 1.14A 3i5uB-5yp3A:
undetectable		 3i5uB-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 HIS A 363
VAL A 384
VAL A 414
ALA A 397
 None
 1.01A 3kp6B-5yp3A:
undetectable		 3kp6B-5yp3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 8 GLY A 592
GLN A 589
LEU A 596
ILE A 607
 None
 0.83A 3nbqC-5yp3A:
2.1		 3nbqC-5yp3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 ALA A 635
GLY A 611
GLY A 633
LEU A 681
ALA A 637
 None
 1.11A 3ou6A-5yp3A:
undetectable		 3ou6A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 LEU A 623
ALA A 635
GLY A 611
GLY A 633
ALA A 637
 None
 0.94A 3ou6A-5yp3A:
undetectable		 3ou6A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 ALA A 635
GLY A 611
GLY A 633
LEU A 681
ALA A 637
 None
 1.10A 3ou6B-5yp3A:
undetectable		 3ou6B-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 LEU A 623
ALA A 635
GLY A 611
GLY A 633
ALA A 637
 None
 0.92A 3ou6B-5yp3A:
undetectable		 3ou6B-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 ALA A 635
GLY A 611
GLY A 633
LEU A 681
ALA A 637
 None
 1.10A 3ou7B-5yp3A:
undetectable		 3ou7B-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 11 LYS A 580
ASP A 588
LEU A 504
THR A 502
GLY A 500
 None
 1.41A 3sfuC-5yp3A:
undetectable		 3sfuC-5yp3A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 4 GLY A 636
GLY A 616
THR A 619
LEU A 681
 None
 0.94A 3si7C-5yp3A:
undetectable
3si7D-5yp3A:
undetectable		 3si7C-5yp3A:
undetectable
3si7D-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 PHE A 155
GLY A 130
GLY A 154
ALA A 156
PHE A 170
 None
 0.94A 3sudB-5yp3A:
undetectable		 3sudB-5yp3A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 TYR A 492
GLN A 533
TYR A 527
TYR A 610
 None
None
PRO  A 802 (-4.7A)
None
 0.88A 3ugrA-5yp3A:
undetectable		 3ugrA-5yp3A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 PRO A 245
ASP A 246
GLU A  91
 None
 0.70A 3v4tC-5yp3A:
undetectable		 3v4tC-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.80A 3w2tA-5yp3A:
34.3		 3w2tA-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.33A 3w2tA-5yp3A:
34.3		 3w2tA-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.03A 3w2tA-5yp3A:
34.3		 3w2tA-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.14A 3w2tA-5yp3A:
34.3		 3w2tA-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.79A 3w2tB-5yp3A:
34.6		 3w2tB-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.32A 3w2tB-5yp3A:
34.6		 3w2tB-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.06A 3w2tB-5yp3A:
34.6		 3w2tB-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.13A 3w2tB-5yp3A:
34.6		 3w2tB-5yp3A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
 0.86A 4ffwA-5yp3A:
35.5		 4ffwA-5yp3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		9 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.47A 4ffwA-5yp3A:
35.5		 4ffwA-5yp3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.13A 4ffwA-5yp3A:
35.5		 4ffwA-5yp3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
VAL A 692
HIS A 721
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
None
ILE  A 801 (-4.5A)
 0.66A 4ffwB-5yp3A:
36.5		 4ffwB-5yp3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.06A 4ffwB-5yp3A:
36.5		 4ffwB-5yp3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 PRO A 421
ARG A 403
GLY A 401
ALA A 413
 None
 1.13A 4g0uA-5yp3A:
undetectable		 4g0uA-5yp3A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 8 GLY A 198
THR A 190
ASN A 199
PHE A 227
 None
 1.25A 4m5mA-5yp3A:
undetectable		 4m5mA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 5 ALA A 719
GLY A 722
ASP A 737
ASP A 727
 None
 1.00A 4n48A-5yp3A:
1.6		 4n48A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 5 THR A 450
THR A 451
THR A 425
HIS A 410
 None
 1.42A 4pgfB-5yp3A:
undetectable		 4pgfB-5yp3A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 LEU A 377
THR A 373
LEU A 364
SER A 355
 None
 0.85A 4pwjB-5yp3A:
undetectable		 4pwjB-5yp3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 5 GLY A 582
THR A 583
GLY A 579
GLU A 585
 None
 1.01A 4v20A-5yp3A:
undetectable		 4v20A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 ASP A 121
ARG A 437
PRO A  48
 None
 1.00A 4wanC-5yp3A:
undetectable		 4wanC-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 10 PHE A 352
ALA A 367
VAL A 330
GLU A 332
LEU A 316
 None
 1.31A 4zmeB-5yp3A:
undetectable		 4zmeB-5yp3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 LEU A 377
THR A 373
LEU A 364
SER A 355
 None
 0.85A 5bojB-5yp3A:
undetectable		 5bojB-5yp3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 7 ALA A 100
GLY A 130
THR A 150
GLU A 132
 None
 1.01A 5bs8A-5yp3A:
undetectable
5bs8B-5yp3A:
2.0
5bs8C-5yp3A:
undetectable		 5bs8A-5yp3A:
12.14
5bs8B-5yp3A:
17.39
5bs8C-5yp3A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 ARG A 306
LYS A 313
GLU A 315
 None
 0.80A 5d0yA-5yp3A:
undetectable		 5d0yA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 11 VAL A 526
VAL A 609
VAL A 524
ILE A 593
LEU A 622
 None
 1.06A 5e4dB-5yp3A:
undetectable		 5e4dB-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 8 LEU A 622
LEU A 561
THR A 534
TYR A 527
 None
None
None
PRO  A 802 (-4.7A)
 1.18A 5hbsA-5yp3A:
undetectable		 5hbsA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 ARG A 106
GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.80A 6b1eB-5yp3A:
34.7		 6b1eB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		10 / 12 GLU A 208
GLU A 209
TYR A 527
SER A 613
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.34A 6b1eB-5yp3A:
34.7		 6b1eB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 GLU A 208
TYR A 527
SER A 613
VAL A 639
TYR A 645
 ILE  A 801 (-3.4A)
PRO  A 802 (-4.7A)
PRO  A 802 (-1.3A)
None
PRO  A 802 (-4.0A)
 1.05A 6b1eB-5yp3A:
34.7		 6b1eB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		5 / 12 TYR A 617
TYR A 645
ASN A 691
VAL A 692
HIS A 721
 None
PRO  A 802 (-4.0A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 1.11A 6b1eB-5yp3A:
34.7		 6b1eB-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		3 / 3 GLY A 152
THR A 150
GLU A 186
 None
 0.65A 6b58A-5yp3A:
undetectable		 6b58A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4
(Pseudoxanthomona
s
mexicana) 		4 / 6 GLU A 456
HIS A 431
ALA A 427
GLN A 426
 None
 1.42A 6f6jC-5yp3A:
undetectable
6f6jD-5yp3A:
undetectable		 6f6jC-5yp3A:
undetectable
6f6jD-5yp3A:
undetectable