SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ypt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 5 HIS A 305
SER A 193
LEU A 107
GLY A 218
 None
 1.02A 1a4lB-5yptA:
undetectable		 1a4lB-5yptA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 8 GLY A 165
GLU A 194
SER A 340
PHE A 267
 None
 0.96A 1ax9A-5yptA:
undetectable		 1ax9A-5yptA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 9 ALA A 176
GLY A 227
ALA A  19
LEU A 386
LEU A 173
 None
 1.09A 1nr6A-5yptA:
undetectable		 1nr6A-5yptA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 7 GLY A 165
GLU A 194
SER A 340
PHE A 267
 None
 1.00A 2ackA-5yptA:
undetectable		 2ackA-5yptA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 6 PHE A 346
SER A 222
GLY A 220
THR A  28
 None
 1.21A 2f7fA-5yptA:
undetectable		 2f7fA-5yptA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 7 ASP A 219
ALA A 342
PHE A  72
THR A 199
 None
 1.07A 2q6oA-5yptA:
undetectable		 2q6oA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 12 ALA A 221
GLY A 220
LEU A 345
SER A 343
MET A 339
 None
 1.33A 3bxoA-5yptA:
undetectable		 3bxoA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 5 PHE A 375
ILE A 277
GLY A 308
HIS A 305
 None
 1.32A 3r0lD-5yptA:
undetectable		 3r0lD-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 11 SER A 340
GLY A 341
GLU A 194
HIS A 305
THR A 134
 None
 1.49A 3r76A-5yptA:
0.4		 3r76A-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 11 SER A 340
GLY A 341
GLU A 194
HIS A 305
THR A 134
 None
 1.49A 3r76B-5yptA:
undetectable		 3r76B-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 5 ASP A 313
LEU A 312
ILE A 277
PRO A 274
 None
 1.10A 3s3vA-5yptA:
undetectable		 3s3vA-5yptA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 12 ALA A 115
LEU A 386
VAL A 372
LEU A 173
ILE A 226
 None
 1.06A 4km2B-5yptA:
undetectable		 4km2B-5yptA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 6 VAL A 130
VAL A 188
ILE A 226
LEU A 345
 None
 0.96A 4l1wB-5yptA:
undetectable		 4l1wB-5yptA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 8 ARG A 387
GLU A 240
GLY A  17
PRO A  18
 None
 1.05A 5kf8A-5yptA:
undetectable		 5kf8A-5yptA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 8 GLU A 240
PRO A 230
GLY A  17
PRO A  18
 None
 1.04A 5kf8A-5yptA:
undetectable		 5kf8A-5yptA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		4 / 7 SER A 343
HIS A 305
GLY A 341
LEU A 333
 None
 0.85A 6btxA-5yptA:
undetectable		 6btxA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5ypt STILBENECARBOXYLATE
SYNTHASE 1
(Marchantia
polymorpha) 		5 / 12 LEU A 270
ASP A 209
VAL A 273
LEU A 276
ILE A 277
 None
 1.04A 6ectA-5yptA:
undetectable		 6ectA-5yptA:
undetectable