SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ypz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5ypz COFB
(Escherichia
coli) 		4 / 8 VAL A 416
SER A 417
ASN A 421
ASP A 419
 None
 1.25A 1hwiB-5ypzA:
undetectable		 1hwiB-5ypzA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5ypz COFB
(Escherichia
coli) 		4 / 6 ARG A 110
ILE A 134
GLY A  46
ALA A  45
 None
 0.99A 1wpuA-5ypzA:
undetectable		 1wpuA-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5ypz COFB
(Escherichia
coli) 		4 / 6 ARG A 110
ILE A 134
GLY A  46
ALA A  45
 None
 1.00A 1wpuB-5ypzA:
undetectable		 1wpuB-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ypz COFB
(Escherichia
coli) 		3 / 3 ASP A 175
ASP A 150
ASN A 144
 None
 0.55A 2bm9D-5ypzA:
undetectable		 2bm9D-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_A_DX2A271_1
(PTERIDINE REDUCTASE
1)		 5ypz COFB
(Escherichia
coli) 		5 / 10 SER A 130
PHE A 129
VAL A  51
LEU A  71
PRO A  70
 None
 1.39A 3jq7A-5ypzA:
undetectable		 3jq7A-5ypzA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5ypz COFB
(Escherichia
coli) 		4 / 8 SER A 130
PHE A 129
LEU A  71
PRO A  70
 None
 1.19A 3jq7B-5ypzA:
undetectable		 3jq7B-5ypzA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5ypz COFB
(Escherichia
coli) 		5 / 12 ILE A  44
ALA A 196
VAL A 208
LEU A 251
LEU A 147
 None
 1.19A 4qzuA-5ypzA:
undetectable		 4qzuA-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5ypz COFB
(Escherichia
coli) 		5 / 12 GLY A 106
GLY A 104
ARG A 110
ASN A  82
PRO A  79
 None
 1.14A 6ce2B-5ypzA:
undetectable		 6ce2B-5ypzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ypz COFB
(Escherichia
coli) 		4 / 8 ASP A 132
HIS A 199
ASP A  49
GLU A  53
 None
 1.22A 6mn4B-5ypzA:
undetectable		 6mn4B-5ypzA:
undetectable