SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 193
LEU A 235
LEU A 214
MET A 182
PHE A 156
 None
 1.25A 1d4fA-5yq5A:
undetectable		 1d4fA-5yq5A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 193
LEU A 235
LEU A 214
MET A 182
PHE A 156
 None
 1.24A 1d4fB-5yq5A:
undetectable		 1d4fB-5yq5A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 193
LEU A 235
LEU A 214
MET A 182
PHE A 156
 None
 1.20A 1d4fD-5yq5A:
undetectable		 1d4fD-5yq5A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 ILE A 174
LEU A 191
ILE A 207
LEU A 203
PRO A 228
 None
 1.07A 1jolB-5yq5A:
undetectable		 1jolB-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 ILE A 174
LEU A 191
ILE A 207
LEU A 203
PRO A 228
 None
 1.07A 1rx8A-5yq5A:
undetectable		 1rx8A-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 169
LEU A 193
LEU A 219
LEU A 188
MET A 211
 None
 1.48A 1sqnA-5yq5A:
undetectable		 1sqnA-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
 None
 1.18A 2j7xA-5yq5A:
undetectable		 2j7xA-5yq5A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		6 / 11 LEU A 240
LEU A 219
SER A 201
LEU A 203
LYS A 204
LEU A 231
 None
 1.47A 2xn5A-5yq5A:
undetectable		 2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 11 SER A  74
SER A  75
LEU A 140
LEU A  96
LEU A 146
 None
 1.07A 2xn5A-5yq5A:
undetectable		 2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		3 / 3 PRO A 161
PHE A 111
LYS A 139
 None
 0.53A 3bjwG-5yq5A:
undetectable		 3bjwG-5yq5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 193
LEU A 235
LEU A 214
MET A 182
PHE A 156
 None
 1.26A 3n58D-5yq5A:
undetectable		 3n58D-5yq5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		4 / 8 VAL A 287
LEU A 269
LEU A 292
ILE A 276
 None
 0.91A 3u5kC-5yq5A:
undetectable		 3u5kC-5yq5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		4 / 8 PHE A 296
ILE A 272
GLY A 288
ASN A 340
 None
 0.95A 4fgjA-5yq5A:
undetectable
4fgjB-5yq5A:
undetectable		 4fgjA-5yq5A:
undetectable
4fgjB-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
 None
 1.16A 4j26A-5yq5A:
undetectable		 4j26A-5yq5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
 None
 1.16A 4j26B-5yq5A:
undetectable		 4j26B-5yq5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 146
ILE A 120
LEU A 117
ILE A  86
VAL A 106
 None
 0.70A 4y0rA-5yq5A:
undetectable		 4y0rA-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 146
LEU A 148
LEU A  96
ILE A 103
VAL A 106
 None
 1.01A 4y0rA-5yq5A:
undetectable		 4y0rA-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 214
PHE A 156
LEU A 177
PHE A 208
VAL A 186
 None
 1.35A 5dlvB-5yq5A:
undetectable		 5dlvB-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5yq5 OSTEOMODULIN
(Homo
sapiens) 		5 / 12 LEU A 193
LEU A 235
LEU A 214
MET A 182
PHE A 156
 None
 1.26A 6gbnC-5yq5A:
undetectable		 6gbnC-5yq5A:
11.03