SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5yqq MEMBRANE-ANCHORED
LIPID-BINDING
PROTEIN YSP2
(Saccharomyces
cerevisiae) 		3 / 3 TRP A1172
ARG A1167
THR A1178
 None
 0.65A 1df7A-5yqqA:
undetectable		 1df7A-5yqqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5yqq MEMBRANE-ANCHORED
LIPID-BINDING
PROTEIN YSP2
(Saccharomyces
cerevisiae) 		3 / 3 ILE A1136
ASP A1140
PHE A1144
 None
 0.64A 1uwjB-5yqqA:
undetectable		 1uwjB-5yqqA:
15.81