SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 12 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
 0.96A 2aclA-5yqrA:
undetectable
2aclE-5yqrA:
undetectable		 2aclA-5yqrA:
18.84
2aclE-5yqrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 6 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.02A 2e1qA-5yqrA:
undetectable		 2e1qA-5yqrA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 6 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.02A 2e1qC-5yqrA:
undetectable		 2e1qC-5yqrA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 10 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
 1.04A 3falC-5yqrA:
undetectable		 3falC-5yqrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
 0.98A 3fc6A-5yqrA:
undetectable		 3fc6A-5yqrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 5 VAL A 149
ILE A   3
PHE A   4
PHE A  67
 None
 1.11A 3owxB-5yqrA:
undetectable		 3owxB-5yqrA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 9 LEU A 133
LEU A 121
ILE A  78
PHE A 114
VAL A 111
 None
 1.39A 3tmzA-5yqrA:
undetectable		 3tmzA-5yqrA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 7 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 3uniA-5yqrA:
undetectable		 3uniA-5yqrA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 HIS A1203
GLU A1268
ASN A1176
 None
 1.01A 4bupB-5yqrA:
undetectable		 4bupB-5yqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 8 MET A   6
SER A   1
TRP A 158
GLY A1159
 None
 0.80A 4xk8a-5yqrA:
undetectable		 4xk8a-5yqrA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 8 ASN A 144
ARG A 145
ARG A 148
THR A  21
 None
 1.32A 5db5A-5yqrA:
undetectable
5db5B-5yqrA:
undetectable		 5db5A-5yqrA:
undetectable
5db5B-5yqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 7 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
 1.16A 5ecnA-5yqrA:
undetectable		 5ecnA-5yqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 12 MET A 102
ALA A  74
VAL A 149
LEU A 121
VAL A  87
 None
 1.27A 5tudD-5yqrA:
undetectable		 5tudD-5yqrA:
11.56