SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 6 LEU A 196
GLU A 181
LEU A 191
LEU A 520
None
0.89A 1mt1D-5yqwA:
undetectable
1mt1E-5yqwA:
undetectable
1mt1D-5yqwA:
18.52
1mt1E-5yqwA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 10 ARG A 436
SER A 359
TYR A 407
ASP A 365
LEU A 484
CBS  A 604 (-3.1A)
None
None
CBS  A 604 (-2.9A)
None
1.49A 1mxfA-5yqwA:
undetectable
1mxfA-5yqwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 ARG A 436
SER A 359
TYR A 407
ASP A 365
LEU A 484
CBS  A 604 (-3.1A)
None
None
CBS  A 604 (-2.9A)
None
1.47A 1mxfB-5yqwA:
undetectable
1mxfB-5yqwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 ARG A 436
SER A 359
TYR A 407
ASP A 365
LEU A 484
CBS  A 604 (-3.1A)
None
None
CBS  A 604 (-2.9A)
None
1.47A 1mxfC-5yqwA:
undetectable
1mxfC-5yqwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 ARG A 436
SER A 359
TYR A 407
ASP A 365
LEU A 484
CBS  A 604 (-3.1A)
None
None
CBS  A 604 (-2.9A)
None
1.49A 1mxfD-5yqwA:
undetectable
1mxfD-5yqwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.10A 1nodB-5yqwA:
undetectable
1nodB-5yqwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.15A 1qomA-5yqwA:
undetectable
1qomA-5yqwA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 7 VAL A 131
VAL A  39
TYR A  35
ARG A 123
None
1.00A 1t46A-5yqwA:
undetectable
1t46A-5yqwA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 12 ASN A 255
ALA A 384
ILE A 382
VAL A 405
PHE A 269
None
1.16A 1udtA-5yqwA:
undetectable
1udtA-5yqwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
None
1.05A 1z11A-5yqwA:
undetectable
1z11A-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
None
1.03A 1z11B-5yqwA:
undetectable
1z11B-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 10 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
None
1.06A 1z11C-5yqwA:
undetectable
1z11C-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 10 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
None
1.03A 1z11D-5yqwA:
undetectable
1z11D-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 TYR A 419
GLY A 299
SER A 298
ILE A 481
HIS A 440
None
None
NI  A 603 (-3.2A)
None
None
1.28A 2a58A-5yqwA:
2.2
2a58E-5yqwA:
undetectable
2a58A-5yqwA:
14.63
2a58E-5yqwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 12 ILE A 481
HIS A 440
TYR A 419
GLY A 299
SER A 298
None
None
None
None
NI  A 603 (-3.2A)
1.28A 2a58B-5yqwA:
undetectable
2a58C-5yqwA:
undetectable
2a58B-5yqwA:
14.63
2a58C-5yqwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 ILE A 481
HIS A 440
TYR A 419
GLY A 299
SER A 298
None
None
None
None
NI  A 603 (-3.2A)
1.27A 2a58C-5yqwA:
2.2
2a58D-5yqwA:
2.2
2a58C-5yqwA:
14.63
2a58D-5yqwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 8 THR A 408
VAL A 405
ASN A 252
ALA A 397
None
1.16A 2ij7C-5yqwA:
undetectable
2ij7C-5yqwA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.05A 2nodB-5yqwA:
undetectable
2nodB-5yqwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 5 PHE A  41
PHE A 122
SER A  90
PHE A  57
None
1.37A 2v0mD-5yqwA:
undetectable
2v0mD-5yqwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 9 ILE A 282
PHE A 249
ALA A 248
VAL A 483
None
0.74A 2vufA-5yqwA:
undetectable
2vufA-5yqwA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 8 PHE A 287
TYR A 394
VAL A 483
LEU A 484
None
0.87A 2w98B-5yqwA:
undetectable
2w98B-5yqwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 12 LEU A 377
LEU A 330
ILE A 382
VAL A 251
VAL A 405
None
1.07A 2ygpA-5yqwA:
undetectable
2ygpA-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 GLU A  43
ASP A 415
TYR A 455
None
0.79A 2yvlB-5yqwA:
undetectable
2yvlB-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 12 VAL A 251
ILE A 481
TYR A 410
TYR A 419
TYR A 424
None
1.34A 3hgiA-5yqwA:
undetectable
3hgiA-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 9 ILE A 135
PHE A  68
ALA A  54
VAL A 140
VAL A 138
None
1.17A 3me6C-5yqwA:
undetectable
3me6C-5yqwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.09A 3nw2A-5yqwA:
undetectable
3nw2A-5yqwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.09A 3nw2B-5yqwA:
undetectable
3nw2B-5yqwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 5 GLY A 515
TRP A 513
ALA A 514
PHE A 391
None
CBS  A 604 (-3.8A)
None
None
1.13A 3wqwA-5yqwA:
undetectable
3wqwA-5yqwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 11 SER A 125
GLY A 104
ASP A 101
VAL A  94
MET A 434
P4G  A 602 (-3.5A)
P4G  A 602 ( 4.2A)
None
None
None
1.48A 4pghC-5yqwA:
undetectable
4pghC-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
5 / 12 LEU A 264
VAL A 405
ALA A 334
LEU A 277
LEU A 377
None
1.11A 5tudA-5yqwA:
2.1
5tudA-5yqwA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 6 VAL A 523
TYR A 185
GLU A  36
ARG A  52
None
1.03A 5z3jA-5yqwA:
undetectable
5z3jA-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
3 / 3 MET A 489
ASP A 365
ARG A 436
CBS  A 604 (-4.1A)
CBS  A 604 (-2.9A)
CBS  A 604 (-3.1A)
1.19A 5z6kA-5yqwA:
undetectable
5z6kA-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio
harveyi)
4 / 7 ASN A  47
ASN A  42
GLU A 518
ARG A 509
None
1.17A 6b8kA-5yqwA:
undetectable
6b8kA-5yqwA:
21.18