SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 560
VAL A 565
GLY A 564
ALA A 582
LEU A 574
 None
 1.17A 2bxgA-5yrpA:
undetectable		 2bxgA-5yrpA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 541
ASP A 542
ASN A 539
ASP A 529
 None
 0.95A 2g72B-5yrpA:
undetectable		 2g72B-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 590
ILE A 591
PRO A 371
TYR A 369
 None
 0.98A 3d9lA-5yrpA:
1.5
3d9lY-5yrpA:
undetectable		 3d9lA-5yrpA:
undetectable
3d9lY-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 509
ASP A 529
ILE A 528
VAL A 549
 None
 0.83A 3fi0E-5yrpA:
undetectable		 3fi0E-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 585
GLU A 566
VAL A 565
ARG A 530
GLU A 476
 None
None
None
None
MG  A 701 (-2.9A)
 1.13A 4k88A-5yrpA:
undetectable		 4k88A-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 507
ASP A 529
ALA A 562
ASP A 506
 None
None
None
MG  A 701 (-2.2A)
 1.16A 4mdaA-5yrpA:
undetectable		 4mdaA-5yrpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 507
ASP A 529
ALA A 562
ASP A 506
 None
None
None
MG  A 701 (-2.2A)
 1.19A 4mdbA-5yrpA:
undetectable		 4mdbA-5yrpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 450
LEU A 420
GLY A 416
ILE A 443
ALA A 385
 None
 1.26A 5j7wC-5yrpA:
undetectable		 5j7wC-5yrpA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.67A 5qgyA-5yrpA:
undetectable		 5qgyA-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.67A 5qgzA-5yrpA:
undetectable		 5qgzA-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.67A 5qh0A-5yrpA:
undetectable		 5qh0A-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.68A 5qh2A-5yrpA:
undetectable		 5qh2A-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.68A 5qh3A-5yrpA:
undetectable		 5qh3A-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.68A 5qh7A-5yrpA:
undetectable		 5qh7A-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.65A 5qhaA-5yrpA:
undetectable		 5qhaA-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 533
VAL A 565
GLN A 583
 None
 0.66A 5qhhA-5yrpA:
undetectable		 5qhhA-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 421
PHE A 427
PHE A 466
LEU A 367
 None
 1.29A 5veuH-5yrpA:
undetectable		 5veuH-5yrpA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 556
ALA A 555
ALA A 534
ALA A 570
THR A 573
 None
 1.24A 6aycA-5yrpA:
undetectable		 6aycA-5yrpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 442
ALA A 383
GLN A 583
ILE A 373
 None
 1.30A 6f6sA-5yrpA:
undetectable
6f6sB-5yrpA:
undetectable		 6f6sA-5yrpA:
22.62
6f6sB-5yrpA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 450
LEU A 420
GLY A 416
ILE A 443
ALA A 385
 None
 1.25A 6qxsD-5yrpA:
undetectable		 6qxsD-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 450
LEU A 420
GLY A 416
ILE A 443
ALA A 385
 None
 1.22A 6qyaB-5yrpA:
undetectable		 6qyaB-5yrpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5yrp SENSORY BOX/RESPONSE
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 450
LEU A 420
GLY A 416
ILE A 443
ALA A 385
 None
 1.22A 6qyaD-5yrpA:
undetectable		 6qyaD-5yrpA:
undetectable