SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5yrz HICA
(Streptococcus
pneumoniae) 		3 / 3 LYS B  28
LYS B  15
VAL B  18
 None
 0.84A 3brfA-5yrzB:
undetectable		 3brfA-5yrzB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 11 GLN A  34
ASP A  12
PHE A  86
PHE A  80
THR A  89
 None
 1.41A 3n23A-5yrzA:
undetectable		 3n23A-5yrzA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 11 GLN A  34
ASP A  12
PHE A  86
PHE A  80
THR A  89
 None
 1.41A 3n23C-5yrzA:
undetectable		 3n23C-5yrzA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 11 GLU A  40
TYR A  21
GLY A  45
ALA A  43
ALA A   7
 None
 1.10A 3nmuB-5yrzA:
undetectable
3nmuJ-5yrzA:
undetectable		 3nmuB-5yrzA:
undetectable
3nmuJ-5yrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 12 GLU A  40
TYR A  21
GLY A  45
ALA A  43
ALA A   7
 None
 1.11A 3nvkF-5yrzA:
undetectable
3nvkJ-5yrzA:
undetectable		 3nvkF-5yrzA:
undetectable
3nvkJ-5yrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5yrz HICB
(Streptococcus
pneumoniae) 		4 / 5 LEU A 108
GLY A 109
ILE A 143
LYS A 147
 None
 1.18A 4ma8C-5yrzA:
undetectable		 4ma8C-5yrzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 12 VAL A  53
GLY A  50
SER A  46
PHE A   9
PHE A  25
 None
 1.12A 6a94A-5yrzA:
undetectable		 6a94A-5yrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 12 VAL A  53
GLY A  50
SER A  46
PHE A   9
PHE A  25
 None
 1.12A 6a94B-5yrzA:
undetectable		 6a94B-5yrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5yrz HICB
(Streptococcus
pneumoniae) 		5 / 11 PHE A   9
ILE A  38
LEU A  42
LEU A   8
ILE A  69
 None
SO4  A 201 (-4.0A)
None
None
None
 1.46A 6fgcA-5yrzA:
undetectable		 6fgcA-5yrzA:
22.22