SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ys3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	5 / 10	PHE A 109 GLY A 65 GLU A 57 GLY A 54 ALA A 53	None ACT A 204 (-3.6A) None None None	1.15A	2ej3B-5ys3A: undetectable	2ej3B-5ys3A: 13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APW_B_DP0B190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	5 / 12	PHE A 135 LEU A 134 ALA A 164 PHE A 17 TYR A 72	ACT A 202 (-4.2A) ACT A 202 (-4.9A) None ACT A 203 ( 3.6A) ACT A 203 (-4.0A)	1.44A	3apwB-5ys3A: undetectable	3apwB-5ys3A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I45_A_NIOA500_1 (TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	4 / 8	PHE A 75 LEU A 24 PHE A 135 LEU A 138	ACT A 202 ( 4.7A) ACT A 202 ( 4.5A) ACT A 202 (-4.2A) ACT A 201 (-4.1A)	1.02A	3i45A-5ys3A: undetectable	3i45A-5ys3A: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_M_TFPM201_1 (PROTEIN S100-A4)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	4 / 7	GLY A 13 PHE A 114 GLY A 65 PHE A 64	None None ACT A 204 (-3.6A) ACT A 204 (-4.8A)	0.76A	3ko0M-5ys3A: undetectable 3ko0P-5ys3A: undetectable	3ko0M-5ys3A: 15.09 3ko0P-5ys3A: 15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SGL_A_SAMA692_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	5 / 12	GLY A 161 GLY A 18 THR A 20 LEU A 24 ASN A 25	None None None ACT A 202 ( 4.5A) ACT A 202 (-3.9A)	1.04A	3sglA-5ys3A: undetectable	3sglA-5ys3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JO9_A_SORA302_0 (RIBITOL 2-DEHYDROGENASE)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	5 / 12	TYR A 72 LEU A 103 GLY A 104 VAL A 108 LEU A 138	ACT A 203 (-4.0A) ACT A 201 ( 4.9A) 78M A 211 ( 4.0A) 78M A 211 (-4.5A) ACT A 201 (-4.1A)	1.39A	5jo9A-5ys3A: undetectable	5jo9A-5ys3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_B_SAMB601_1 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5ys3	SUCCINATE-ACETATE PERMEASE (Citrobacter koseri)	4 / 7	PHE A 17 ALA A 49 GLY A 46 GLY A 42	ACT A 203 ( 3.6A) None None None	0.77A	5ybbB-5ys3A: undetectable	5ybbB-5ys3A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EJ3_B_GBNB914_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",5,"PHE A 109;GLY A  65;GLU A  57;GLY A  54;ALA A  53","None;ACT A 204 (-3.6A);None;None;None","1.15A","2ej3B-5ys3A:undetectable","2ej3B-5ys3A:13.68"],["3APW_B_DP0B190_1","ALPHA-1-ACID GLYCOPROTEIN 2","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",5,"PHE A 135;LEU A 134;ALA A 164;PHE A  17;TYR A  72","ACT A 202 (-4.2A);ACT A 202 (-4.9A);None;ACT A 203 ( 3.6A);ACT A 203 (-4.0A)","1.44A","3apwB-5ys3A:undetectable","3apwB-5ys3A:19.23"],["3I45_A_NIOA500_1","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",4,"PHE A  75;LEU A  24;PHE A 135;LEU A 138","ACT A 202 ( 4.7A);ACT A 202 ( 4.5A);ACT A 202 (-4.2A);ACT A 201 (-4.1A)","1.02A","3i45A-5ys3A:undetectable","3i45A-5ys3A:14.74"],["3KO0_M_TFPM201_1","PROTEIN S100-A4;PROTEIN S100-A4","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",4,"GLY A  13;PHE A 114;GLY A  65;PHE A  64","None;None;ACT A 204 (-3.6A);ACT A 204 (-4.8A)","0.76A","3ko0M-5ys3A:undetectable;3ko0P-5ys3A:undetectable","3ko0M-5ys3A:15.09;3ko0P-5ys3A:15.09"],["3SGL_A_SAMA692_0","TRNA 5-METHYLAMINOMETHYL-2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",5,"GLY A 161;GLY A  18;THR A  20;LEU A  24;ASN A  25","None;None;None;ACT A 202 ( 4.5A);ACT A 202 (-3.9A)","1.04A","3sglA-5ys3A:undetectable","3sglA-5ys3A:undetectable"],["5JO9_A_SORA302_0","RIBITOL 2-DEHYDROGENASE","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",5,"TYR A  72;LEU A 103;GLY A 104;VAL A 108;LEU A 138","ACT A 203 (-4.0A);ACT A 201 ( 4.9A);78M A 211 ( 4.0A);78M A 211 (-4.5A);ACT A 201 (-4.1A)","1.39A","5jo9A-5ys3A:undetectable","5jo9A-5ys3A:undetectable"],["5YBB_B_SAMB601_1","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5ys3","SUCCINATE-ACETATE PERMEASE","Citrobacter koseri",4,"PHE A  17;ALA A  49;GLY A  46;GLY A  42","ACT A 203 ( 3.6A);None;None;None","0.77A","5ybbB-5ys3A:undetectable","5ybbB-5ys3A:undetectable"]]