SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ysb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		4 / 6 VAL A 161
GLY A 162
ALA A 176
LEU A 180
 None
 0.69A 1e7bB-5ysbA:
undetectable		 1e7bB-5ysbA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 LEU A  37
VAL A  64
VAL A 114
SER A 122
ASN A 303
 None
 1.36A 2y00A-5ysbA:
undetectable		 2y00A-5ysbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 LEU A  37
VAL A  64
VAL A 114
SER A 122
ASN A 303
 None
 1.35A 2y00B-5ysbA:
undetectable		 2y00B-5ysbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		3 / 3 PRO A 167
LEU A 158
ARG A 183
 None
 0.79A 3aqiB-5ysbA:
undetectable		 3aqiB-5ysbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		4 / 5 ILE A 379
PHE A 404
ASP A 406
GLU A 409
 None
 1.14A 3kp6A-5ysbA:
undetectable
3kp6B-5ysbA:
undetectable		 3kp6A-5ysbA:
21.99
3kp6B-5ysbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		4 / 7 LEU A 333
ASP A 348
ALA A 345
TYR A 357
 None
 0.99A 3rodD-5ysbA:
undetectable		 3rodD-5ysbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 PHE A 152
GLY A 300
LEU A 299
SER A 297
PHE A 126
 None
 1.32A 3tbgA-5ysbA:
undetectable		 3tbgA-5ysbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 11 ALA A 166
LEU A 158
LEU A 178
GLY A 189
LEU A 151
 None
 0.96A 3zosA-5ysbA:
undetectable
3zosB-5ysbA:
undetectable		 3zosA-5ysbA:
17.76
3zosB-5ysbA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		4 / 5 HIS A 419
HIS A  75
GLU A 100
HIS A 418
 ZN  A 514 (-2.7A)
ZN  A 501 (-3.0A)
ZN  A 501 (-2.1A)
ZN  A 501 ( 2.9A)
 1.39A 4a7bB-5ysbA:
undetectable		 4a7bB-5ysbA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 LEU A 289
PRO A 167
ALA A 177
TYR A 231
GLY A 208
 None
None
None
None
ZN  A 508 ( 4.7A)
 1.00A 4l9qA-5ysbA:
undetectable		 4l9qA-5ysbA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		4 / 6 PRO A 194
ILE A 236
VAL A 229
THR A 199
 None
 1.11A 4xe5A-5ysbA:
undetectable		 4xe5A-5ysbA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 THR A 199
THR A 198
GLY A 204
THR A 228
SER A 298
 None
 1.36A 5lf3b-5ysbA:
undetectable		 5lf3b-5ysbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5ysb LIN1841 PROTEIN
(Listeria
innocua) 		5 / 12 THR A 199
THR A 198
GLY A 204
THR A 228
SER A 298
 None
 1.36A 5lf3N-5ysbA:
undetectable		 5lf3N-5ysbA:
17.59