SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ysm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 7 GLY A 360
HIS A 361
THR A 335
ILE A 307
 HEM  A 501 (-4.1A)
None
None
HEM  A 501 (-4.4A)
 0.94A 1gtnF-5ysmA:
undetectable
1gtnG-5ysmA:
undetectable		 1gtnF-5ysmA:
undetectable
1gtnG-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 273
GLY A 268
LEU A 265
ARG A 402
PRO A 414
 None
 1.11A 1y4lA-5ysmA:
undetectable		 1y4lA-5ysmA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		3 / 3 SER A 301
GLU A 295
ASP A 344
 None
 0.89A 2avdB-5ysmA:
undetectable		 2avdB-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 9 LEU A 121
PHE A 106
LEU A 231
LEU A 241
ALA A 250
 None
HEM  A 501 (-4.6A)
None
None
None
 1.24A 2bxeA-5ysmA:
undetectable		 2bxeA-5ysmA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 121
PHE A 106
LEU A 231
LEU A 241
ALA A 250
 None
HEM  A 501 (-4.6A)
None
None
None
 1.24A 2bxpA-5ysmA:
2.0		 2bxpA-5ysmA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 THR A 242
ALA A 237
ALA A 235
ILE A 228
LEU A 367
 None
None
None
None
HEM  A 501 ( 4.2A)
 1.12A 2nyrA-5ysmA:
undetectable		 2nyrA-5ysmA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 7 ILE A 415
PRO A 166
GLY A 379
MET A 376
 None
None
None
HEM  A 501 ( 4.2A)
 1.06A 2pnjB-5ysmA:
undetectable		 2pnjB-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 GLY A 409
LEU A 272
GLY A 268
GLY A 266
LEU A 296
 None
 1.09A 2zbpA-5ysmA:
undetectable		 2zbpA-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 107
LEU A 252
ILE A 255
ALA A 256
THR A 260
 HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
 0.80A 3a50A-5ysmA:
39.8		 3a50A-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 11 ILE A 107
LEU A 252
ILE A 255
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.7A)
None
 0.75A 3a51A-5ysmA:
39.7		 3a51A-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 107
LEU A 252
ILE A 255
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.7A)
None
 0.74A 3a51D-5ysmA:
39.3		 3a51D-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 107
ILE A 255
ALA A 256
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
 0.93A 3a51E-5ysmA:
39.3		 3a51E-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 4 LEU A 241
ARG A 129
LEU A 121
ALA A 235
 None
 1.21A 3b9mA-5ysmA:
undetectable		 3b9mA-5ysmA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 5 ILE A 170
SER A 167
PRO A 166
PRO A 164
 None
 1.39A 3bjwC-5ysmA:
undetectable		 3bjwC-5ysmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		3 / 3 ALA A 256
THR A 260
CYH A 366
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.3A)
 0.50A 3e4eA-5ysmA:
31.1		 3e4eA-5ysmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		3 / 3 ALA A 256
THR A 260
CYH A 366
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.3A)
 0.45A 3e4eB-5ysmA:
31.0		 3e4eB-5ysmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		3 / 3 LYS A  19
ILE A 322
PHE A 317
 None
 0.96A 3j7zS-5ysmA:
undetectable
3j7za-5ysmA:
undetectable		 3j7zS-5ysmA:
undetectable
3j7za-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 383
GLY A 266
ALA A 162
ALA A 165
LEU A 413
 None
 0.94A 3p5nA-5ysmA:
2.7		 3p5nA-5ysmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 383
GLY A 266
ALA A 162
ALA A 165
LEU A 413
 None
 0.94A 3p5nB-5ysmA:
2.7		 3p5nB-5ysmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 5 PRO A 166
ILE A 170
TYR A 380
MET A 158
 None
 1.32A 3phaA-5ysmA:
undetectable		 3phaA-5ysmA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 11 ARG A 220
ALA A 250
ILE A 227
ILE A 232
ILE A 228
 None
 0.76A 3s53B-5ysmA:
undetectable		 3s53B-5ysmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 107
ILE A 255
ALA A 256
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
 1.02A 3s79A-5ysmA:
29.7		 3s79A-5ysmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 5 LEU A 297
LEU A 296
LEU A 267
SER A 263
 None
 0.86A 3vhuA-5ysmA:
undetectable		 3vhuA-5ysmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 11 ILE A 307
LEU A  69
VAL A  68
LEU A 357
TYR A  62
 HEM  A 501 (-4.4A)
None
None
None
None
 1.07A 4g1bB-5ysmA:
undetectable		 4g1bB-5ysmA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 307
LEU A  69
VAL A  68
LEU A 357
TYR A  62
 HEM  A 501 (-4.4A)
None
None
None
None
 1.08A 4g1bD-5ysmA:
undetectable		 4g1bD-5ysmA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 TRP A 342
GLU A  63
ALA A  65
VAL A  59
GLY A  43
 None
 1.16A 4hfpD-5ysmA:
undetectable		 4hfpD-5ysmA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 10 ILE A 107
ILE A 255
ALA A 256
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
 0.95A 4kq8A-5ysmA:
29.7		 4kq8A-5ysmA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 371
ILE A 170
PHE A 125
GLY A 368
GLY A 257
 None
None
None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.3A)
 0.91A 4rzvA-5ysmA:
undetectable		 4rzvA-5ysmA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 10 PHE A 317
ALA A 318
VAL A  68
LEU A 357
THR A 335
 None
 1.18A 4zmeB-5ysmA:
undetectable		 4zmeB-5ysmA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		4 / 7 GLU A 245
ARG A 116
ASP A 238
ALA A 237
 None
 0.71A 4zz8A-5ysmA:
undetectable		 4zz8A-5ysmA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ARG A 220
ALA A 250
ILE A 227
ILE A 232
ILE A 228
 None
 0.79A 5e5kB-5ysmA:
undetectable		 5e5kB-5ysmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		3 / 3 VAL A 390
LEU A 300
MET A 264
 None
None
HEM  A 501 (-4.8A)
 0.77A 5ikrA-5ysmA:
undetectable		 5ikrA-5ysmA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 VAL A 390
LEU A 300
MET A 264
GLY A 268
LEU A 279
 None
None
HEM  A 501 (-4.8A)
None
None
 1.08A 5iktA-5ysmA:
undetectable		 5iktA-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 107
ILE A 255
ALA A 256
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
 1.01A 5jkvA-5ysmA:
29.7		 5jkvA-5ysmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5ysm CYTOCHROME P450
(Amycolatopsis
mediterranei) 		5 / 12 ILE A 255
ALA A 256
THR A 260
VAL A 303
LEU A 406
 None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
None
 0.93A 5jkvA-5ysmA:
29.7		 5jkvA-5ysmA:
11.06