SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ysq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ASP A  11
GLY A  25
GLY A  26
THR A  74
ASN A  78
 INS  A 301 (-2.7A)
INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
None
INS  A 301 (-3.0A)
 0.88A 1liiA-5ysqA:
22.9		 1liiA-5ysqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 LEU A  37
GLY A 231
GLY A 233
THR A  33
ASN A 114
 None
INS  A 301 ( 4.7A)
SO4  A 302 (-3.2A)
None
None
 1.01A 1likA-5ysqA:
24.6		 1likA-5ysqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
 None
 1.07A 1uduB-5ysqA:
undetectable		 1uduB-5ysqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
 None
 0.92A 1xozA-5ysqA:
undetectable		 1xozA-5ysqA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ASP A  11
GLY A  25
GLY A  26
GLN A 141
ASP A 234
 INS  A 301 (-2.7A)
INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
INS  A 301 (-3.0A)
INS  A 301 ( 4.9A)
 0.96A 2c49A-5ysqA:
26.6		 2c49A-5ysqA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 10 PHE A  98
THR A  74
LEU A 116
GLY A  26
VAL A  43
 None
None
INS  A 301 (-4.8A)
INS  A 301 (-3.8A)
None
 1.30A 2cp4A-5ysqA:
undetectable		 2cp4A-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 4 ARG A 232
PHE A 221
THR A 204
ALA A 206
 SO4  A 303 ( 2.9A)
None
SO4  A 302 (-3.2A)
SO4  A 303 (-3.4A)
 1.36A 2e1qB-5ysqA:
0.0		 2e1qB-5ysqA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 5 ARG A 232
PHE A 221
THR A 204
ALA A 206
 SO4  A 303 ( 2.9A)
None
SO4  A 302 (-3.2A)
SO4  A 303 (-3.4A)
 1.37A 2e1qD-5ysqA:
undetectable		 2e1qD-5ysqA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 11 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
 None
 1.06A 2h42A-5ysqA:
undetectable		 2h42A-5ysqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 6 THR A 230
THR A 235
ASN A  61
ASP A  60
 INS  A 301 (-4.7A)
None
None
None
 1.28A 2okcA-5ysqA:
2.8		 2okcA-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
 None
 1.01A 3b2rA-5ysqA:
undetectable		 3b2rA-5ysqA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 7 LEU A 186
ASP A 173
SER A 189
THR A 181
 None
SO4  A 302 (-3.6A)
None
None
 1.28A 3dzgB-5ysqA:
3.0		 3dzgB-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ASP A  11
GLY A  25
GLY A  26
THR A  74
ASN A  78
 INS  A 301 (-2.7A)
INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
None
INS  A 301 (-3.0A)
 0.83A 4dc3B-5ysqA:
24.8		 4dc3B-5ysqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 5ysq TM0415
(Thermotoga
maritima) 		6 / 12 ASP A  11
GLY A  25
GLY A  26
THR A 230
GLY A 231
ASP A 234
 INS  A 301 (-2.7A)
INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
INS  A 301 (-4.7A)
INS  A 301 ( 4.7A)
INS  A 301 ( 4.9A)
 1.08A 4e3aB-5ysqA:
27.8		 4e3aB-5ysqA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 5ysq TM0415
(Thermotoga
maritima) 		6 / 12 GLY A  25
GLY A  26
LEU A  91
THR A 230
GLY A 231
ASP A 234
 INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
None
INS  A 301 (-4.7A)
INS  A 301 ( 4.7A)
INS  A 301 ( 4.9A)
 1.23A 4e3aB-5ysqA:
27.8		 4e3aB-5ysqA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 9 GLY A  25
GLY A  24
PHE A  57
GLY A  26
PHE A  55
 INS  A 301 (-3.4A)
None
None
INS  A 301 (-3.8A)
None
 1.32A 4h2fA-5ysqA:
undetectable		 4h2fA-5ysqA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 9 GLY A  25
GLY A  24
PHE A  57
GLY A  26
PHE A  55
 INS  A 301 (-3.4A)
None
None
INS  A 301 (-3.8A)
None
 1.40A 4h2gA-5ysqA:
3.0		 4h2gA-5ysqA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 5 PHE A 121
HIS A 112
PHE A 143
LEU A 169
 None
 1.44A 4o8zA-5ysqA:
4.6		 4o8zA-5ysqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ASN A  78
GLY A  26
ILE A  32
SER A   9
PHE A  57
 INS  A 301 (-3.0A)
INS  A 301 (-3.8A)
None
INS  A 301 ( 4.5A)
None
 1.20A 4obwC-5ysqA:
4.5		 4obwC-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 ASP A  11
GLY A  25
GLY A  26
GLN A 141
ASP A 234
 INS  A 301 (-2.7A)
INS  A 301 (-3.4A)
INS  A 301 (-3.8A)
INS  A 301 (-3.0A)
INS  A 301 ( 4.9A)
 1.21A 4ubeA-5ysqA:
26.3		 4ubeA-5ysqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 GLY A 231
ASP A 234
PHE A  55
PHE A  57
ALA A  22
 INS  A 301 ( 4.7A)
INS  A 301 ( 4.9A)
None
None
None
 1.41A 4wh5A-5ysqA:
undetectable		 4wh5A-5ysqA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5ysq TM0415
(Thermotoga
maritima) 		4 / 7 PHE A  57
PHE A  55
GLY A  24
GLY A  26
 None
None
None
INS  A 301 (-3.8A)
 1.03A 5n9xA-5ysqA:
3.2		 5n9xA-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ysq TM0415
(Thermotoga
maritima) 		4 / 8 LEU A  58
VAL A  63
VAL A  43
PHE A   4
 None
 0.70A 5y9mX-5ysqA:
undetectable		 5y9mX-5ysqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5ysq TM0415
(Thermotoga
maritima) 		5 / 12 VAL A  28
ASP A  11
GLU A 176
GLU A 120
GLY A   6
 None
INS  A 301 (-2.7A)
SO4  A 302 ( 4.9A)
None
None
 1.46A 6gnfC-5ysqA:
6.9		 6gnfC-5ysqA:
9.21