SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ysx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5ysx -
(-) 		6 / 11 GLY A 113
ALA A 136
ASP A 135
GLY A 133
VAL A  82
ILE A 154
 None
 1.02A 1ohrA-5ysxA:
undetectable		 1ohrA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 5ysx -
(-) 		5 / 10 GLY A 113
ALA A 136
ASP A 135
VAL A  82
ILE A 154
 None
 0.93A 2aquA-5ysxA:
undetectable		 2aquA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5ysx -
(-) 		6 / 11 GLY A 113
ALA A 136
ASP A 135
GLY A 133
VAL A  82
ILE A 154
 None
 1.10A 2aquB-5ysxA:
undetectable		 2aquB-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 5ysx -
(-) 		6 / 11 GLY A 113
ALA A 136
ASP A 135
GLY A 133
VAL A  82
ILE A 154
 None
 1.06A 2fxeB-5ysxA:
undetectable		 2fxeB-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ysx -
(-) 		5 / 9 ALA A 136
GLY A 155
ILE A 154
TYR A  80
HIS A  72
 None
 1.20A 2zm9A-5ysxA:
undetectable		 2zm9A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5ysx -
(-) 		4 / 4 LEU A 233
ASP A  48
VAL A 239
THR A  55
 None
 1.24A 3cyxB-5ysxA:
undetectable		 3cyxB-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 5ysx -
(-) 		6 / 10 GLY A 113
ALA A 136
ASP A 135
GLY A 133
VAL A  82
ILE A 154
 None
 1.09A 3ekyA-5ysxA:
undetectable		 3ekyA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 5ysx -
(-) 		5 / 11 GLY A 113
ALA A 136
GLY A 133
VAL A  82
ILE A 154
 None
 0.92A 3em4A-5ysxA:
undetectable		 3em4A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ysx -
(-) 		5 / 12 PRO A 172
PHE A  21
PHE A 107
VAL A 137
VAL A 138
 None
 1.45A 4yfbF-5ysxA:
undetectable		 4yfbF-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qgnA-5ysxA:
undetectable		 5qgnA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qgyA-5ysxA:
undetectable		 5qgyA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.64A 5qgzA-5ysxA:
undetectable		 5qgzA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.66A 5qh0A-5ysxA:
undetectable		 5qh0A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.64A 5qh2A-5ysxA:
undetectable		 5qh2A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qh3A-5ysxA:
undetectable		 5qh3A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.64A 5qh5A-5ysxA:
undetectable		 5qh5A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qh6A-5ysxA:
undetectable		 5qh6A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qh7A-5ysxA:
undetectable		 5qh7A-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ysx -
(-) 		3 / 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.66A 5qhhA-5ysxA:
undetectable		 5qhhA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5ysx -
(-) 		5 / 12 PHE A 170
ILE A 154
GLY A  67
PHE A  65
VAL A 164
 None
 1.13A 5x66F-5ysxA:
undetectable		 5x66F-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5ysx -
(-) 		4 / 5 THR A  83
THR A 163
GLN A 117
ASP A 160
 None
 1.14A 6ectA-5ysxA:
undetectable		 6ectA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5ysx -
(-) 		4 / 5 THR A  83
THR A 163
GLN A 117
ASP A 160
 None
 1.16A 6ecxA-5ysxA:
undetectable		 6ecxA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5ysx -
(-) 		4 / 5 GLN A 117
ASP A 160
ASN A 165
TYR A  80
 None
 1.49A 6iftA-5ysxA:
undetectable		 6iftA-5ysxA:
undetectable