SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 7 VAL A  58
GLY A  82
THR A 227
ILE A  63
 None
 0.80A 1gtnC-5yt0A:
undetectable
1gtnD-5yt0A:
undetectable		 1gtnC-5yt0A:
undetectable
1gtnD-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5yt0 ARCHAEAL RIBOSOMAL
STALK PROTEIN AP1
PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 4 LEU A 226
PRO A 207
ILE A 196
LEU B 105
 None
 1.13A 1ya4C-5yt0A:
undetectable		 1ya4C-5yt0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
 None
 1.02A 2b7zA-5yt0A:
undetectable		 2b7zA-5yt0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.97A 2oipA-5yt0A:
undetectable		 2oipA-5yt0A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.97A 2oipB-5yt0A:
undetectable		 2oipB-5yt0A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.98A 2oipD-5yt0A:
undetectable		 2oipD-5yt0A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
 None
 0.93A 3gguA-5yt0A:
undetectable		 3gguA-5yt0A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.98A 3hj3A-5yt0A:
undetectable		 3hj3A-5yt0A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.97A 3hj3B-5yt0A:
undetectable		 3hj3B-5yt0A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.83A 3hj3C-5yt0A:
undetectable		 3hj3C-5yt0A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ALA A 140
LEU A 172
LEU A 192
PHE A 193
THR A 160
 None
 0.97A 3hj3D-5yt0A:
undetectable		 3hj3D-5yt0A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 8 VAL A 318
MET A 292
TYR A 313
ILE A 263
 None
 0.99A 3remA-5yt0A:
undetectable		 3remA-5yt0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 8 VAL A 318
MET A 292
TYR A 313
ILE A 263
 None
 0.99A 3remB-5yt0A:
undetectable		 3remB-5yt0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 4 PHE A 107
TYR A 230
ILE A  57
LEU A  84
 None
 1.27A 3sudA-5yt0A:
undetectable		 3sudA-5yt0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 5 PHE A 107
TYR A 230
ILE A  57
LEU A  84
 None
 1.25A 3sueC-5yt0A:
1.8		 3sueC-5yt0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 9 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
 None
 0.87A 3u7sA-5yt0A:
undetectable		 3u7sA-5yt0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 9 GLY A 317
ALA A 316
GLY A 244
ILE A 334
VAL A 312
 None
 0.88A 3u7sB-5yt0A:
undetectable		 3u7sB-5yt0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 TYR A 335
ILE A 320
GLU A 353
TYR A 264
VAL A 318
 None
 0.91A 4a97A-5yt0A:
undetectable
4a97B-5yt0A:
undetectable		 4a97A-5yt0A:
14.24
4a97B-5yt0A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		3 / 3 ARG A 175
GLN A 174
GLU A 178
 None
 0.87A 4tvtA-5yt0A:
undetectable		 4tvtA-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 9 ALA A 139
ASP A 113
GLY A  28
LEU A  32
LEU A 219
 None
None
GDP  A 500 (-3.4A)
None
None
 1.20A 5dqfA-5yt0A:
undetectable		 5dqfA-5yt0A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 4 VAL A 259
ALA A 322
ILE A 283
THR A 285
 None
 1.10A 5e4dB-5yt0A:
undetectable		 5e4dB-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 7 HIS A  52
ILE A 263
VAL A 262
GLN A  16
 None
 1.07A 5kkzC-5yt0A:
undetectable
5kkzE-5yt0A:
undetectable		 5kkzC-5yt0A:
undetectable
5kkzE-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 7 HIS A  52
ILE A 263
VAL A 262
GLN A  16
 None
 1.03A 5kkzK-5yt0A:
undetectable
5kkzQ-5yt0A:
undetectable		 5kkzK-5yt0A:
undetectable
5kkzQ-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 7 HIS A  52
ILE A 263
VAL A 262
GLN A  16
 None
 1.15A 5kkzM-5yt0A:
undetectable
5kkzO-5yt0A:
undetectable		 5kkzM-5yt0A:
undetectable
5kkzO-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		4 / 7 GLY A 317
ALA A 316
GLY A 244
ILE A 334
 None
 0.68A 5kqyB-5yt0A:
undetectable		 5kqyB-5yt0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 11 LEU A 290
ALA A 322
ILE A 283
ILE A 273
ILE A 320
 None
 1.30A 5kr2B-5yt0A:
undetectable		 5kr2B-5yt0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		3 / 3 THR A  50
PRO A  59
ASP A  61
 None
 0.75A 5l8dB-5yt0A:
undetectable		 5l8dB-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 12 ILE A 109
VAL A 208
ILE A  74
VAL A  76
PHE A  85
 None
 0.79A 5mugA-5yt0A:
undetectable		 5mugA-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		3 / 3 THR A  50
PRO A  59
ASP A  61
 None
 0.75A 5mwuB-5yt0A:
undetectable		 5mwuB-5yt0A:
undetectable