SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 7 TYR A 224
GLU A 216
THR A 214
MET A 226
 None
 1.22A 1tv8A-5ytiA:
undetectable		 1tv8A-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 8 PHE A 136
ARG A 163
ALA A  72
LEU A 345
 None
 1.15A 1x8vA-5ytiA:
undetectable		 1x8vA-5ytiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 7 ILE A 331
GLN A  96
LEU A 110
LEU A 117
 None
 1.03A 2qqcB-5ytiA:
undetectable
2qqcC-5ytiA:
undetectable		 2qqcB-5ytiA:
14.91
2qqcC-5ytiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 7 LEU A 110
LEU A 117
ILE A 331
GLN A  96
 None
 1.01A 2qqcA-5ytiA:
undetectable
2qqcF-5ytiA:
undetectable		 2qqcA-5ytiA:
17.50
2qqcF-5ytiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 7 LEU A 110
LEU A 117
ILE A 331
GLN A  96
 None
 1.06A 2qqcG-5ytiA:
undetectable
2qqcJ-5ytiA:
undetectable		 2qqcG-5ytiA:
17.50
2qqcJ-5ytiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		5 / 12 ASN A 190
GLY A 191
VAL A 276
SER A 289
ILE A 195
 None
 1.28A 3k13A-5ytiA:
undetectable		 3k13A-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		5 / 12 ASN A 190
GLY A 191
VAL A 276
SER A 289
ILE A 195
 None
 1.28A 3k13B-5ytiA:
undetectable		 3k13B-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		5 / 12 ASN A 190
GLY A 191
VAL A 276
SER A 289
ILE A 195
 None
 1.28A 3k13C-5ytiA:
undetectable		 3k13C-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		3 / 3 ASN A 324
ALA A  97
ARG A 107
 None
 0.57A 5cvtB-5ytiA:
undetectable		 5cvtB-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		3 / 3 ASP A  70
ASN A  65
PHE A 164
 None
 0.79A 5dsgB-5ytiA:
3.8		 5dsgB-5ytiA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		4 / 5 PRO A 280
GLY A 204
THR A 205
ASN A 202
 None
 1.23A 5x23A-5ytiA:
undetectable		 5x23A-5ytiA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		3 / 3 LEU A 352
LEU A  73
ARG A 348
 None
 0.61A 6fgcA-5ytiA:
undetectable		 6fgcA-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL
(Legionella
pneumophila) 		3 / 3 LEU A 352
LEU A  73
ARG A 348
 None
 0.64A 6fgdA-5ytiA:
undetectable		 6fgdA-5ytiA:
undetectable