SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 4 HIS A 229
LEU A 243
LEU A 248
LEU A 275
 None
 1.02A 1a4lD-5yu1A:
undetectable		 1a4lD-5yu1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 ILE A 144
ALA A 208
SER A 130
LEU A 228
THR A 209
 NAD  A 402 ( 4.8A)
NAD  A 402 (-4.4A)
None
None
NAD  A 402 (-4.0A)
 1.20A 1ddsB-5yu1A:
undetectable		 1ddsB-5yu1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 10 ILE A 144
ALA A 208
SER A 130
ILE A 205
THR A 209
 NAD  A 402 ( 4.8A)
NAD  A 402 (-4.4A)
None
None
NAD  A 402 (-4.0A)
 1.29A 1j3jA-5yu1A:
undetectable		 1j3jA-5yu1A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 GLN A 149
ALA A 119
ILE A 192
ASP A 170
HIS A 175
 NAD  A 402 (-3.7A)
None
None
NAD  A 402 (-2.8A)
NAD  A 402 (-3.9A)
 1.11A 1kxhA-5yu1A:
undetectable		 1kxhA-5yu1A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1502_0
(RAS-RELATED PROTEIN
RAB-9A)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 4 HIS A 257
ILE A  38
GLN A 278
PHE A 304
 None
 1.50A 1s8fA-5yu1A:
2.4
1s8fB-5yu1A:
0.0		 1s8fA-5yu1A:
undetectable
1s8fB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 10 LEU A 279
ASP A 256
GLY A 303
GLY A 265
THR A 254
 None
None
NAD  A 402 ( 3.2A)
NA  A 401 (-3.5A)
None
 0.88A 1t7iA-5yu1A:
undetectable		 1t7iA-5yu1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 4 ASP A 221
LEU A 248
LEU A 245
LEU A 247
 None
 1.26A 1u18A-5yu1A:
undetectable		 1u18A-5yu1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 GLY A 303
HIS A 257
THR A 118
ALA A 208
ALA A 235
 NAD  A 402 ( 3.2A)
None
YCP  A 403 (-4.0A)
NAD  A 402 (-4.4A)
NA  A 401 ( 4.1A)
 0.96A 2gluB-5yu1A:
6.4		 2gluB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A  23
MET A  24
ARG A  26
ILE A  27
ARG A  30
 None
 0.94A 2lbdA-5yu1A:
undetectable		 2lbdA-5yu1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 120
GLY A 123
LEU A 116
VAL A  11
GLY A  19
 None
 1.32A 2vmyB-5yu1A:
undetectable		 2vmyB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 ALA A 311
SER A 126
PHE A 299
GLY A 303
THR A 302
 None
None
None
NAD  A 402 ( 3.2A)
None
 1.22A 2zifA-5yu1A:
undetectable		 2zifA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 ALA A 311
SER A 126
PHE A 299
GLY A 303
THR A 302
 None
None
None
NAD  A 402 ( 3.2A)
None
 1.17A 2zifB-5yu1A:
undetectable		 2zifB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 143
ALA A 156
GLY A 147
VAL A 188
THR A 186
 None
None
NAD  A 402 (-3.3A)
None
None
 1.03A 3c6gA-5yu1A:
undetectable		 3c6gA-5yu1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 143
ALA A 156
GLY A 147
VAL A 188
THR A 186
 None
None
NAD  A 402 (-3.3A)
None
None
 1.03A 3c6gB-5yu1A:
undetectable		 3c6gB-5yu1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 4 THR A 118
VAL A 233
GLY A 147
THR A 146
 YCP  A 403 (-4.0A)
NAD  A 402 (-4.2A)
NAD  A 402 (-3.3A)
None
 1.04A 3cflA-5yu1A:
undetectable		 3cflA-5yu1A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 SER A 206
LEU A 157
LEU A 161
PRO A 195
VAL A 204
 None
 1.27A 3dcjA-5yu1A:
3.9
3dcjB-5yu1A:
3.8		 3dcjA-5yu1A:
undetectable
3dcjB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 7 LEU A 243
GLU A 266
ASP A 300
THR A 209
 None
None
NA  A 401 (-3.6A)
NAD  A 402 (-4.0A)
 1.07A 3dzgB-5yu1A:
2.4		 3dzgB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 6 GLN A 268
LEU A 270
GLU A 266
LEU A 248
 None
 0.91A 3h5gA-5yu1A:
undetectable
3h5gC-5yu1A:
undetectable		 3h5gA-5yu1A:
undetectable
3h5gC-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 GLY A  51
ILE A  61
GLY A 265
ALA A 261
LEU A  48
 None
None
NA  A 401 (-3.5A)
None
None
 0.84A 3hs6B-5yu1A:
undetectable		 3hs6B-5yu1A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		3 / 3 ARG A  68
THR A  78
THR A 109
 None
 0.64A 3k2hB-5yu1A:
2.0		 3k2hB-5yu1A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 11 GLY A 234
ALA A 235
ASP A 236
VAL A 238
GLY A 239
 NAD  A 402 (-3.7A)
NA  A 401 ( 4.1A)
NAD  A 402 (-3.9A)
None
None
 0.67A 3ufnA-5yu1A:
undetectable		 3ufnA-5yu1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 10 LEU A 279
ASP A 256
GLY A 303
GLY A 265
THR A 254
 None
None
NAD  A 402 ( 3.2A)
NA  A 401 (-3.5A)
None
 0.96A 4njtB-5yu1A:
undetectable		 4njtB-5yu1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 117
LEU A  23
MET A  24
HIS A 155
THR A 152
 None
 1.21A 4ojbA-5yu1A:
undetectable		 4ojbA-5yu1A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 117
LEU A  23
MET A  24
HIS A 155
THR A 152
 None
 1.17A 4okbA-5yu1A:
undetectable		 4okbA-5yu1A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 10 PRO A 217
VAL A 224
ILE A 230
LEU A 228
LEU A 270
 None
 1.18A 5ienB-5yu1A:
1.5		 5ienB-5yu1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 5 ILE A 198
LEU A 247
HIS A 229
VAL A 204
 None
 1.17A 5jmnB-5yu1A:
undetectable		 5jmnB-5yu1A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		3 / 3 GLN A 260
THR A 302
ASP A 256
 None
 0.93A 5k9dA-5yu1A:
undetectable		 5k9dA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		3 / 3 GLU A 259
HIS A 257
ARG A  49
 None
None
YCP  A 403 ( 3.5A)
 0.84A 5uunA-5yu1A:
undetectable		 5uunA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		4 / 5 GLU A 307
THR A 302
GLN A 260
MET A  65
 None
None
None
YCP  A 403 (-3.8A)
 1.45A 6fgdA-5yu1A:
2.7		 6fgdA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 5yu1 LYSINE
CYCLODEAMINASE
(Streptomyces
pristinaespirali
s) 		5 / 12 ASP A 236
GLN A 268
ASP A 300
ASP A 221
THR A 207
 NAD  A 402 (-3.9A)
None
NA  A 401 (-3.6A)
None
None
 1.39A 6fzbB-5yu1A:
undetectable		 6fzbB-5yu1A:
25.00