SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 ASP A 561
ARG A 566
ILE A 303
 None
 0.81A 1a4gB-5yv5A:
undetectable		 1a4gB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 6 LEU A 256
ARG A 244
TYR A 275
VAL A 194
 None
 0.90A 1db1A-5yv5A:
undetectable		 1db1A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 8 ASP A 478
THR A 378
HIS A 512
ILE A 375
 MG  A 604 ( 3.9A)
MG  A 604 ( 3.1A)
None
ADP  A 602 (-4.2A)
 0.94A 1ei6C-5yv5A:
2.8		 1ei6C-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 VAL A 283
SER A 294
VAL A 486
HIS A 268
LEU A 273
 None
 1.18A 1ie9A-5yv5A:
undetectable		 1ie9A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 LEU A 226
LEU A 182
LEU A 198
LEU A 256
TYR A 232
 None
 1.29A 3d90B-5yv5A:
undetectable		 3d90B-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 ARG A 244
GLU A 528
TYR A 534
 None
 0.85A 3k37B-5yv5A:
undetectable		 3k37B-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_A_ACTA901_0
(PYRANOSE 2-OXIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 5 SER A 113
GLN A 165
HIS A 268
ASN A 108
 MG  A 603 ( 2.0A)
MG  A 603 (-2.7A)
None
ADP  A 601 (-3.9A)
 1.49A 3lskA-5yv5A:
0.4		 3lskA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 6 SER A 113
GLN A 165
HIS A 268
ASN A 108
 MG  A 603 ( 2.0A)
MG  A 603 (-2.7A)
None
ADP  A 601 (-3.9A)
 1.45A 3lskB-5yv5A:
undetectable		 3lskB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 9 ILE A 280
ILE A 303
PHE A 306
ALA A 271
LEU A 273
 None
 1.06A 3ozvB-5yv5A:
undetectable		 3ozvB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 TYR A 587
ASP A 513
ASP A 518
 None
 0.71A 3r24A-5yv5A:
undetectable		 3r24A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 ALA A 222
LEU A 204
ALA A 185
VAL A 174
VAL A 178
 None
 1.07A 3rukA-5yv5A:
undetectable		 3rukA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 5 LEU A 441
ARG A 494
ILE A 323
ARG A 319
 None
 1.43A 3ticA-5yv5A:
undetectable		 3ticA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 ILE A 367
VAL A 366
SER A 521
ILE A 517
ILE A 369
 None
 1.13A 3vrjA-5yv5A:
undetectable
3vrjC-5yv5A:
undetectable		 3vrjA-5yv5A:
undetectable
3vrjC-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 ASP A 513
ILE A 554
PHE A 558
PHE A 325
LEU A 307
 None
 1.38A 4j03A-5yv5A:
undetectable		 4j03A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 9 LEU A  90
PRO A 125
ALA A 140
PHE A 141
LEU A 119
 None
 1.41A 4la0B-5yv5A:
undetectable		 4la0B-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 ARG A 246
GLU A 479
ARG A 489
 None
MG  A 604 (-4.4A)
None
 0.99A 4mwvA-5yv5A:
undetectable		 4mwvA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 ARG A 489
GLU A 236
ARG A 246
 None
MG  A 603 (-4.2A)
None
 0.85A 4mwvA-5yv5A:
undetectable		 4mwvA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 LEU A  90
ALA A 120
TRP A 134
PHE A 150
VAL A 137
 None
 1.32A 4nc3A-5yv5A:
undetectable		 4nc3A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 5 LEU A 204
ASP A 186
GLU A 180
VAL A 174
 None
 1.30A 4nkvA-5yv5A:
undetectable		 4nkvA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 9 LEU A 211
GLY A 214
VAL A 203
VAL A 178
LEU A 182
 None
 1.17A 4qd3A-5yv5A:
undetectable		 4qd3A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 SER A 239
LEU A 200
LEU A 198
SER A 238
LEU A 225
 None
 1.18A 4yiaA-5yv5A:
undetectable		 4yiaA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 ASP A 513
ARG A 331
ARG A 560
 None
 0.98A 5eajB-5yv5A:
undetectable		 5eajB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 ILE A 474
LEU A 508
VAL A 356
ILE A 395
LEU A 345
 None
 0.99A 5ienB-5yv5A:
undetectable		 5ienB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 6 GLY A 291
THR A 110
TYR A 290
GLY A 109
 None
ADP  A 601 (-4.6A)
None
ADP  A 601 (-3.8A)
 0.89A 5k4pA-5yv5A:
undetectable		 5k4pA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		3 / 3 GLN A 580
THR A 557
ASP A 577
 None
 0.84A 5k9dA-5yv5A:
undetectable		 5k9dA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 ALA A 495
LEU A 468
LEU A 469
ILE A 444
LEU A 420
 None
 1.05A 5toaA-5yv5A:
undetectable		 5toaA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 LEU A 273
SER A 277
LYS A  97
ILE A 303
GLY A 302
 None
 1.41A 6dlzA-5yv5A:
undetectable
6dlzD-5yv5A:
undetectable		 6dlzA-5yv5A:
undetectable
6dlzD-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 ILE A 303
GLY A 302
LEU A 273
SER A 277
LYS A  97
 None
 1.40A 6dlzB-5yv5A:
undetectable
6dlzC-5yv5A:
undetectable		 6dlzB-5yv5A:
undetectable
6dlzC-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 LEU A 273
SER A 277
LYS A  97
ILE A 303
GLY A 302
 None
 1.40A 6dm1A-5yv5A:
undetectable
6dm1D-5yv5A:
undetectable		 6dm1A-5yv5A:
undetectable
6dm1D-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 10 ILE A 303
GLY A 302
LEU A 273
SER A 277
LYS A  97
 None
 1.40A 6dm1B-5yv5A:
undetectable
6dm1C-5yv5A:
undetectable		 6dm1B-5yv5A:
undetectable
6dm1C-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 12 LEU A  90
ALA A 120
TRP A 134
PHE A 150
VAL A 137
 None
 1.27A 6drxA-5yv5A:
undetectable		 6drxA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 5 ARG A 255
ALA A 250
TYR A 275
ILE A 554
 None
 1.39A 6f6sA-5yv5A:
undetectable
6f6sB-5yv5A:
undetectable		 6f6sA-5yv5A:
undetectable
6f6sB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		5 / 9 SER A 553
GLY A 368
SER A 521
VAL A 514
ILE A 517
 None
 1.42A 6giqA-5yv5A:
undetectable
6giqE-5yv5A:
undetectable
6giqI-5yv5A:
undetectable		 6giqA-5yv5A:
undetectable
6giqE-5yv5A:
undetectable
6giqI-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 4 LYS A 427
LEU A 469
ALA A 425
LEU A 420
 None
 1.43A 6gnrA-5yv5A:
undetectable		 6gnrA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 4 LYS A 427
LEU A 469
ALA A 425
LEU A 420
 None
 1.44A 6gnrB-5yv5A:
undetectable		 6gnrB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5yv5 ATPASE RIL
(Pyrococcus
furiosus) 		4 / 8 TYR A  83
PHE A  88
VAL A  80
TYR A  91
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.6A)
None
None
 1.12A 6huoC-5yv5A:
undetectable
6huoD-5yv5A:
undetectable		 6huoC-5yv5A:
undetectable
6huoD-5yv5A:
undetectable