SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		5 / 12 ALA A 233
LEU A 308
GLY A 236
TYR A 278
LEU A 265
 None
None
None
None
AF9  A 405 (-4.6A)
 0.98A 1qabF-5yveA:
undetectable		 1qabF-5yveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		5 / 9 THR A  94
ILE A 303
GLY A 302
TYR A 278
ARG A 304
 None
 1.31A 2y7wA-5yveA:
undetectable		 2y7wA-5yveA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		4 / 7 ILE A 243
GLY A 244
PHE A 181
ILE A  56
 None
 0.86A 2y7wC-5yveA:
undetectable		 2y7wC-5yveA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA191_1
(DIHYDROFOLATE
REDUCTASE)		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		4 / 4 ASP A 210
PRO A 214
LYS A 176
PHE A 174
 None
 1.25A 3n0hA-5yveA:
0.0		 3n0hA-5yveA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		4 / 7 THR A 235
LEU A 232
THR A  94
VAL A 218
 None
 1.07A 5ov9A-5yveA:
undetectable		 5ov9A-5yveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 5yve P2X PURINOCEPTOR 3
(Homo
sapiens) 		4 / 5 GLN A  50
VAL A 246
ASP A 248
ASN A 312
 None
 0.49A 5svlA-5yveA:
30.7		 5svlA-5yveA:
undetectable