SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5yvf -
(-) 		5 / 12 GLU A 393
GLN A 300
HIS A 220
PHE A 328
TYR A 332
 None
 1.36A 1o86A-5yvfA:
undetectable		 1o86A-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 5yvf -
(-) 		4 / 8 PHE A 160
CYH A 206
TYR A 164
ARG A 215
 None
 0.96A 1xqlA-5yvfA:
undetectable
1xqlB-5yvfA:
undetectable		 1xqlA-5yvfA:
undetectable
1xqlB-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5yvf -
(-) 		4 / 8 TYR A 164
ARG A 215
PHE A 160
CYH A 206
 None
 0.99A 1xqlA-5yvfA:
undetectable
1xqlB-5yvfA:
undetectable		 1xqlA-5yvfA:
undetectable
1xqlB-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5yvf -
(-) 		5 / 12 PHE A  65
ALA A  96
ARG A 238
CYH A 206
TYR A 164
 None
 1.41A 2qm9A-5yvfA:
2.1		 2qm9A-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 5yvf -
(-) 		4 / 7 THR A  92
ARG A 217
MET A 169
LEU A 170
 None
 1.03A 2rezA-5yvfA:
1.6		 2rezA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5yvf -
(-) 		4 / 6 TYR A 208
ILE A 137
ASN A  69
LEU A 107
 None
 1.29A 2wekB-5yvfA:
undetectable		 2wekB-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5yvf -
(-) 		3 / 3 ARG A 217
VAL A 145
THR A 140
 None
 0.57A 3cyxA-5yvfA:
undetectable		 3cyxA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5yvf -
(-) 		5 / 12 PHE A 160
PHE A  65
LEU A 162
PHE A 219
GLY A  71
 None
 1.18A 4kykA-5yvfA:
undetectable
4kykB-5yvfA:
undetectable		 4kykA-5yvfA:
undetectable
4kykB-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5yvf -
(-) 		3 / 3 MET A 343
GLN A 373
TYR A 390
 None
 0.99A 4udcA-5yvfA:
undetectable		 4udcA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5yvf -
(-) 		4 / 6 PHE A 391
PHE A  65
SER A 269
VAL A 270
 None
 1.23A 5hesA-5yvfA:
undetectable		 5hesA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5yvf -
(-) 		4 / 6 GLU A 204
THR A 166
TYR A 164
PHE A 160
 None
 1.37A 5lrbA-5yvfA:
undetectable		 5lrbA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5yvf -
(-) 		4 / 5 ILE A 232
PHE A  77
ASN A 108
TYR A 135
 None
 1.24A 6a93B-5yvfA:
undetectable		 6a93B-5yvfA:
undetectable