SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		4 / 4 ALA A 144
VAL A 146
PHE A 113
THR A  55
 None
 1.23A 2pkkA-5yw5A:
undetectable		 2pkkA-5yw5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		5 / 10 ILE A 150
ALA A  44
LEU A 120
LEU A  75
VAL A  74
 None
 0.97A 3o02A-5yw5A:
undetectable
3o02B-5yw5A:
undetectable		 3o02A-5yw5A:
12.99
3o02B-5yw5A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ARG A  63
GLU A  61
THR A  60
 None
 0.82A 3v4tA-5yw5A:
undetectable		 3v4tA-5yw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ARG A  83
LYS A  84
LYS A  87
 None
 1.26A 4k50A-5yw5A:
undetectable		 4k50A-5yw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ARG A  83
LYS A  84
LYS A  87
 None
 1.26A 4k50E-5yw5A:
undetectable		 4k50E-5yw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ARG A  83
LYS A  84
LYS A  87
 None
 1.21A 4k50I-5yw5A:
undetectable		 4k50I-5yw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		6 / 12 LEU A 120
GLU A  61
PHE A  65
GLY A  68
ALA A  72
PHE A  79
 None
 0.98A 4retA-5yw5A:
undetectable		 4retA-5yw5A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		5 / 12 LEU A 120
GLU A  61
GLY A  68
ALA A  72
PHE A  79
 None
 1.01A 4retC-5yw5A:
undetectable		 4retC-5yw5A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5yw5 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		5 / 12 ILE A  26
ILE A  10
PHE A 175
THR A  39
ASN A   2
 None
 1.16A 5lg3J-5yw5A:
undetectable		 5lg3J-5yw5A:
12.75